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| U | Pumas UNAM | - | Cruz Azul | 2:1 (2:0) | ||
| R | Cruz Azul | - | Pumas UNAM | 0:0 (0:0) | ||
| U: 06.04.2022 04:00 | R: 13.04.2022 04:00 | Winnaars: Pumas UNAM | ||||
| U | Seattle Sounders | - | New York City FC | 3:1 (2:1) | ||
| R | New York City FC | - | Seattle Sounders | 1:1 (0:1) | ||
| U: 07.04.2022 04:00 | R: 14.04.2022 03:00 | Winnaars: Seattle Sounders | ||||
