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| U | Santos de Guápiles | - | Forge FC | 3:1 (2:1) | ||
| R | Forge FC | - | Santos de Guápiles | 3:0 (1:0) | ||
| U: 21.10.2021 00:00 | R: 03.11.2021 01:00 | Winnaars: Forge FC | ||||
| U | Deportivo Saprissa | - | Comunicaciones | 4:3 (2:2) | ||
| R | Comunicaciones | - | Deportivo Saprissa | 2:1 (1:1) | ||
| U: 22.10.2021 02:00 | R: 04.11.2021 02:00 | Winnaars: Comunicaciones | ||||
| U | Marathón | - | Motagua | 0:2 (0:1) | ||
| R | Motagua | - | Marathón | 2:0 (0:0) | ||
| U: 22.10.2021 04:00 | R: 03.11.2021 03:15 | Winnaars: Motagua | ||||
