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| U | FBC Melgar | - | Caracas FC | 2:0 (1:0) | ||
| R | Caracas FC | - | FBC Melgar | 2:1 (1:0) | ||
| U: 20.02.2019 01:30 | R: 27.02.2019 01:30 | Winnaars: FBC Melgar | ||||
| U | Talleres de Córdoba | - | Palestino | 1:2 (1:0) | ||
| R | Palestino | - | Talleres de Córdoba | 2:2 (1:2) | ||
| U: 20.02.2019 23:15 | R: 27.02.2019 23:15 | Winnaars: Palestino | ||||
| U | Defensor Sporting | - | Atlético Mineiro | 0:2 (0:1) | ||
| R | Atlético Mineiro | - | Defensor Sporting | 0:0 (0:0) | ||
| U: 21.02.2019 01:30 | R: 28.02.2019 01:30 | Winnaars: Atlético Mineiro | ||||
| U | Libertad | - | Atlético Nacional | 1:0 (0:0) | ||
| R | Atlético Nacional | - | Libertad | 4:5 (1:0, 1:0) d.p. | ||
| U: 22.02.2019 01:30 | R: 01.03.2019 01:30 | Winnaars: Libertad | ||||
