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| U | Libertad | - | Palmeiras | 1:1 (0:1) | ||
| R | Palmeiras | - | Libertad | 3:0 (1:0) | ||
| U: 09.12.2020 01:30 | R: 16.12.2020 01:30 | Winnaars: Palmeiras | ||||
| U | Grêmio Porto Alegre | - | Santos FC | 1:1 (0:1) | ||
| R | Santos FC | - | Grêmio Porto Alegre | 4:1 (2:0) | ||
| U: 09.12.2020 23:15 | R: 16.12.2020 23:15 | Winnaars: Santos FC | ||||
| U | River Plate | - | Nacional | 2:0 (0:0) | ||
| R | Nacional | - | River Plate | 2:6 (1:2) | ||
| U: 11.12.2020 01:30 | R: 18.12.2020 01:30 | Winnaars: River Plate | ||||
| U | Racing Club | - | Boca Juniors | 1:0 (0:0) | ||
| R | Boca Juniors | - | Racing Club | 2:0 (1:0) | ||
| U: 17.12.2020 01:30 | R: 24.12.2020 01:30 | Winnaars: Boca Juniors | ||||
