 |
 |
|
|
| U | San Lorenzo | - | Santos FC | 1:3 (0:2) | ||
| R | Santos FC | - | San Lorenzo | 2:2 (1:0) | ||
| U: 07.04.2021 02:30 | R: 14.04.2021 02:30 | Winnaars: Santos FC | ||||
| U | Libertad | - | Atlético Nacional | 1:0 (0:0) | ||
| R | Atlético Nacional | - | Libertad | 4:1 (1:1) | ||
| U: 08.04.2021 02:30 | R: 15.04.2021 02:30 | Winnaars: Atlético Nacional | ||||
| U | Bolívar | - | Atlético Junior | 2:1 (1:1) | ||
| R | Atlético Junior | - | Bolívar | 3:0 (1:0) | ||
| U: 09.04.2021 02:30 | R: 16.04.2021 02:30 | Winnaars: Atlético Junior | ||||
| U | Independiente del Valle | - | Grêmio Porto Alegre | 2:1 (0:1) | ||
| R | Grêmio Porto Alegre | - | Independiente del Valle | 1:2 (1:1) | ||
| U: 10.04.2021 00:15 | R: 15.04.2021 00:15 | Winnaars: Independiente del Valle | ||||
