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| U | São Paulo FC | - | Palmeiras | 1:1 (0:0) | ||
| R | Palmeiras | - | São Paulo FC | 3:0 (1:0) | ||
| U: 11.08.2021 02:30 | R: 18.08.2021 02:30 | Winnaars: Palmeiras | ||||
| U | Club Olimpia | - | Flamengo RJ | 1:4 (1:2) | ||
| R | Flamengo RJ | - | Club Olimpia | 5:1 (2:1) | ||
| U: 12.08.2021 00:15 | R: 19.08.2021 00:15 | Winnaars: Flamengo RJ | ||||
| U | River Plate | - | Atlético Mineiro | 0:1 (0:0) | ||
| R | Atlético Mineiro | - | River Plate | 3:0 (2:0) | ||
| U: 12.08.2021 02:30 | R: 19.08.2021 02:30 | Winnaars: Atlético Mineiro | ||||
| U | Fluminense RJ | - | Barcelona | 2:2 (1:0) | ||
| R | Barcelona | - | Fluminense RJ | 1:1 (0:0) | ||
| U: 13.08.2021 02:30 | R: 20.08.2021 02:30 | Winnaars: Barcelona | ||||
