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| U | Montevideo City Torque | - | Barcelona | 1:1 (0:1) | ||
| R | Barcelona | - | Montevideo City Torque | 8:7 (0:0, 0:0) d.p. | ||
| U: 09.02.2022 01:30 | R: 16.02.2022 01:30 | Winnaars: Barcelona | ||||
| U | Deportivo Lara | - | Bolívar | 2:3 (2:3) | ||
| R | Bolívar | - | Deportivo Lara | 4:0 (1:0) | ||
| U: 09.02.2022 23:15 | R: 16.02.2022 23:15 | Winnaars: Bolívar | ||||
| U | Universidad Cesar Vallejo | - | Club Olimpia | 0:1 (0:1) | ||
| R | Club Olimpia | - | Universidad Cesar Vallejo | 2:0 (1:0) | ||
| U: 10.02.2022 01:30 | R: 17.02.2022 01:30 | Winnaars: Club Olimpia | ||||
