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| U | Emelec | - | Atlético Mineiro | 1:1 (0:1) | ||
| R | Atlético Mineiro | - | Emelec | 1:0 (0:0) | ||
| U: 29.06.2022 00:15 | R: 06.07.2022 00:15 | Winnaars: Atlético Mineiro | ||||
| U | Corinthians SP | - | Boca Juniors | 0:0 (0:0) | ||
| R | Boca Juniors | - | Corinthians SP | 5:6 (0:0, 0:0) d.p. | ||
| U: 29.06.2022 02:30 | R: 06.07.2022 02:30 | Winnaars: Corinthians SP | ||||
| U | Athletico Paranaense | - | Libertad | 2:1 (2:1) | ||
| R | Libertad | - | Athletico Paranaense | 1:1 (1:0) | ||
| U: 29.06.2022 02:30 | R: 06.07.2022 02:30 | Winnaars: Athletico Paranaense | ||||
| U | Cerro Porteño | - | Palmeiras | 0:3 (0:0) | ||
| R | Palmeiras | - | Cerro Porteño | 5:0 (1:0) | ||
| U: 30.06.2022 00:15 | R: 07.07.2022 00:15 | Winnaars: Palmeiras | ||||
| U | Talleres de Córdoba | - | Colón de Santa Fe | 1:1 (0:0) | ||
| R | Colón de Santa Fe | - | Talleres de Córdoba | 0:2 (0:0) | ||
| U: 30.06.2022 00:15 | R: 07.07.2022 00:15 | Winnaars: Talleres de Córdoba | ||||
| U | Deportes Tolima | - | Flamengo RJ | 0:1 (0:1) | ||
| R | Flamengo RJ | - | Deportes Tolima | 7:1 (2:0) | ||
| U: 30.06.2022 02:30 | R: 07.07.2022 02:30 | Winnaars: Flamengo RJ | ||||
| U | Vélez Sarsfield | - | River Plate | 1:0 (1:0) | ||
| R | River Plate | - | Vélez Sarsfield | 0:0 (0:0) | ||
| U: 30.06.2022 02:30 | R: 07.07.2022 02:30 | Winnaars: Vélez Sarsfield | ||||
| U | Fortaleza | - | Estudiantes | 1:1 (0:0) | ||
| R | Estudiantes | - | Fortaleza | 3:0 (1:0) | ||
| U: 01.07.2022 02:30 | R: 08.07.2022 02:30 | Winnaars: Estudiantes | ||||
