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| U | Defensor Sporting | - | Independiente | 1:0 (0:0) | ||
| R | Independiente | - | Defensor Sporting | 4:2 (3:1) | ||
| U: 29.09.2010 02:15 | R: 20.10.2010 00:20 | Winnaars: Independiente | ||||
| U | Banfield | - | Deportes Tolima | 2:0 (2:0) | ||
| R | Deportes Tolima | - | Banfield | 3:0 (2:0) | ||
| U: 30.09.2010 02:15 | R: 13.10.2010 03:30 | Winnaars: Deportes Tolima | ||||
| U | Newell's Old Boys | - | San José | 6:0 (3:0) | ||
| R | San José | - | Newell's Old Boys | 2:0 (1:0) | ||
| U: 07.10.2010 02:15 | R: 22.10.2010 02:45 | Winnaars: Newell's Old Boys | ||||
| U | Unión San Felipe | - | LDU Quito | 4:2 (2:1) | ||
| R | LDU Quito | - | Unión San Felipe | 6:1 (2:1) | ||
| U: 13.10.2010 01:15 | R: 20.10.2010 03:00 | Winnaars: LDU Quito | ||||
| U | Goiás - GO | - | Peñarol | 1:0 (1:0) | ||
| R | Peñarol | - | Goiás - GO | 3:2 (2:1) | ||
| U: 14.10.2010 00:30 | R: 20.10.2010 23:30 | Winnaars: Goiás - GO | ||||
| U | Atlético Mineiro | - | Santa Fe | 2:0 (1:0) | ||
| R | Santa Fe | - | Atlético Mineiro | 1:0 (0:0) | ||
| U: 14.10.2010 03:00 | R: 21.10.2010 02:00 | Winnaars: Atlético Mineiro | ||||
| U | Emelec | - | Avaí - SC | 2:1 (0:0) | ||
| R | Avaí - SC | - | Emelec | 3:1 (0:1) | ||
| U: 14.10.2010 03:00 | R: 22.10.2010 00:15 | Winnaars: Avaí - SC | ||||
| U | Universitario de Sucre | - | Palmeiras | 0:1 (0:1) | ||
| R | Palmeiras | - | Universitario de Sucre | 3:1 (2:0) | ||
| U: 15.10.2010 02:15 | R: 21.10.2010 02:00 | Winnaars: Palmeiras | ||||
