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| U | Nacional | - | Atlético Goianiense | 0:1 (0:1) | ||
| R | Atlético Goianiense | - | Nacional | 3:0 (2:0) | ||
| U: 03.08.2022 00:15 | R: 10.08.2022 00:15 | Winnaars: Atlético Goianiense | ||||
| U | Deportivo Táchira | - | Independiente del Valle | 0:1 (0:1) | ||
| R | Independiente del Valle | - | Deportivo Táchira | 4:1 (2:1) | ||
| U: 03.08.2022 02:30 | R: 10.08.2022 02:30 | Winnaars: Independiente del Valle | ||||
| U | São Paulo FC | - | Ceará - CE | 1:0 (0:0) | ||
| R | Ceará - CE | - | São Paulo FC | 3:4 (1:0, 2:1) d.p. | ||
| U: 04.08.2022 00:15 | R: 11.08.2022 00:15 | Winnaars: São Paulo FC | ||||
| U | FBC Melgar | - | Internacional | 0:0 (0:0) | ||
| R | Internacional | - | FBC Melgar | 1:3 (0:0, 0:0) d.p. | ||
| U: 05.08.2022 00:15 | R: 12.08.2022 00:15 | Winnaars: FBC Melgar | ||||
