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| 17.04.2022 | 17:00 | FK Jablonec | - | Slavia Praag | 1:2 (0:1) | |
| 17:00 | FC Fastav Zlín | - | FK Mladá Boleslav | 1:2 (0:1) | ||
| 17:00 | FK Pardubice | - | FK Teplice | 2:0 (1:0) | ||
| 17:00 | Viktoria Plzeň | - | Baník Ostrava | 2:1 (1:0) | ||
| 17:00 | FC Hradec Králové | - | Sigma Olomouc | 3:0 (1:0) | ||
| 17:00 | Dynamo České Budějovice | - | Bohemians Praha 1905 | 2:1 (1:1) | ||
| 17:00 | Sparta Praag | - | 1. FC Slovácko | 3:1 (2:1) | ||
| 17:00 | Slovan Liberec | - | MFK Karviná | 2:1 (1:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praag | 29 | 22 | 4 | 3 | 68:19 | 49 | 70 |
| 2 |
|
Viktoria Plzeň | 29 | 21 | 6 | 2 | 51:19 | 32 | 69 |
| 3 |
|
Sparta Praag | 29 | 20 | 6 | 3 | 65:30 | 35 | 66 |
| 4 |
|
1. FC Slovácko | 29 | 17 | 5 | 7 | 48:30 | 18 | 56 |
| 5 |
|
Baník Ostrava | 29 | 13 | 9 | 7 | 53:39 | 14 | 48 |
| 6 |
|
FC Hradec Králové | 29 | 9 | 12 | 8 | 37:39 | -2 | 39 |
| 7 |
|
FK Mladá Boleslav | 29 | 11 | 5 | 13 | 45:46 | -1 | 38 |
| 8 |
|
Slovan Liberec | 29 | 10 | 7 | 12 | 29:36 | -7 | 37 |
| 9 |
|
Dynamo České Budějovice | 29 | 9 | 9 | 11 | 39:44 | -5 | 36 |
| 10 |
|
Sigma Olomouc | 29 | 8 | 10 | 11 | 37:37 | 0 | 34 |
| 11 |
|
FC Fastav Zlín | 29 | 8 | 6 | 15 | 36:50 | -14 | 30 |
| 12 |
|
FK Jablonec | 29 | 4 | 14 | 11 | 22:44 | -22 | 26 |
| 13 |
|
Bohemians Praha 1905 | 29 | 6 | 7 | 16 | 33:55 | -22 | 25 |
| 14 |
|
FK Teplice | 29 | 7 | 3 | 19 | 27:48 | -21 | 24 |
| 15 |
|
FK Pardubice | 29 | 5 | 9 | 15 | 33:64 | -31 | 24 |
| 16 |
|
MFK Karviná | 29 | 2 | 8 | 19 | 27:50 | -23 | 14 |
| Play-offs | |
| Play-offs | |
| Promotie en degradatie |
