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| 11.05.2022 | 17:00 | MFK Chrudim | - | Zbrojovka Brno | 3:2 (1:1) | |
| 17:00 | FK Dukla Praha | - | FC Sellier & Bellot Vlašim | 1:1 (1:0) | ||
| 17:00 | Vysočina Jihlava | - | 1. FK Příbram | 2:1 (1:0) | ||
| 17:00 | FK Fotbal Třinec | - | MFK Vyškov | 1:0 (0:0) | ||
| 17:00 | SK Líšeň | - | Sparta Praag B | 1:0 (1:0) | ||
| 17:00 | FK MAS Táborsko | - | Viktoria Žižkov | 1:0 (1:0) | ||
| 17:00 | 1. SK Prostějov | - | FK Varnsdorf | 0:4 (0:1) | ||
| 17:00 | SFC Opava | - | FK Ústí nad Labem | 2:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 29 | 22 | 2 | 5 | 60:28 | 32 | 68 |
| 2 |
|
SFC Opava | 29 | 14 | 9 | 6 | 46:30 | 16 | 51 |
| 3 |
|
FC Sellier & Bellot Vlašim | 29 | 15 | 5 | 9 | 58:38 | 20 | 50 |
| 4 |
|
SK Líšeň | 29 | 14 | 8 | 7 | 44:30 | 14 | 50 |
| 5 |
|
Sparta Praag B | 29 | 13 | 6 | 10 | 48:35 | 13 | 45 |
| 6 |
|
FK Varnsdorf | 29 | 13 | 5 | 11 | 47:35 | 12 | 44 |
| 7 |
|
Vysočina Jihlava | 29 | 11 | 8 | 10 | 29:34 | -5 | 41 |
| 8 |
|
FK MAS Táborsko | 29 | 10 | 9 | 10 | 32:33 | -1 | 39 |
| 9 |
|
FK Dukla Praha | 29 | 10 | 8 | 11 | 39:40 | -1 | 38 |
| 10 |
|
MFK Chrudim | 29 | 9 | 10 | 10 | 30:34 | -4 | 37 |
| 11 |
|
1. FK Příbram | 29 | 9 | 8 | 12 | 36:47 | -11 | 35 |
| 12 |
|
MFK Vyškov | 29 | 9 | 7 | 13 | 42:43 | -1 | 34 |
| 13 |
|
1. SK Prostějov | 29 | 10 | 4 | 15 | 28:48 | -20 | 34 |
| 14 |
|
FK Fotbal Třinec | 29 | 9 | 6 | 14 | 36:51 | -15 | 33 |
| 15 |
|
FK Ústí nad Labem | 29 | 5 | 10 | 14 | 23:47 | -24 | 25 |
| 16 |
|
Viktoria Žižkov | 29 | 2 | 9 | 18 | 26:51 | -25 | 15 |
| Promotie | |
| Play-offs | |
| Degradatie |
