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| 22.04.2022 | 20:45 | Huddersfield Town | - | Barnsley FC | 2:1 (2:0) | |
| 23.04.2022 | 13:30 | Luton Town | - | Blackpool FC | 1:1 (1:0) | |
| 16:00 | AFC Bournemouth | - | Fulham FC | 1:1 (0:0) | ||
| 16:00 | Birmingham City | - | Millwall FC | 2:2 (0:0) | ||
| 16:00 | Derby County | - | Bristol City | 1:3 (0:2) | ||
| 16:00 | Hull City | - | Reading FC | 3:0 (1:0) | ||
| 16:00 | Peterborough United | - | Nottingham Forest | 0:1 (0:1) | ||
| 16:00 | Sheffield United | - | Cardiff City | 1:0 (0:0) | ||
| 16:00 | Stoke City | - | Queens Park Rangers | 1:0 (1:0) | ||
| 16:00 | Swansea City | - | Middlesbrough FC | 1:1 (0:0) | ||
| 16:00 | West Bromwich Albion | - | Coventry City | 0:0 (0:0) | ||
| 25.04.2022 | 20:30 | Preston North End | - | Blackburn Rovers | 1:4 (1:3) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Fulham FC | 44 | 26 | 9 | 9 | 99:39 | 60 | 87 |
| 2 |
|
AFC Bournemouth | 44 | 23 | 13 | 8 | 70:39 | 31 | 82 |
| 3 |
|
Nottingham Forest | 44 | 22 | 10 | 12 | 67:38 | 29 | 76 |
| 4 |
|
Huddersfield Town | 44 | 21 | 13 | 10 | 60:46 | 14 | 76 |
| 5 |
|
Luton Town | 44 | 20 | 12 | 12 | 62:48 | 14 | 72 |
| 6 |
|
Sheffield United | 44 | 19 | 12 | 13 | 56:44 | 12 | 69 |
| 7 |
|
Middlesbrough FC | 44 | 19 | 10 | 15 | 55:45 | 10 | 67 |
| 8 |
|
Blackburn Rovers | 44 | 18 | 12 | 14 | 57:46 | 11 | 66 |
| 9 |
|
Millwall FC | 44 | 17 | 15 | 12 | 50:44 | 6 | 66 |
| 10 |
|
Coventry City | 44 | 17 | 12 | 15 | 58:56 | 2 | 63 |
|
Queens Park Rangers | 44 | 18 | 9 | 17 | 58:56 | 2 | 63 | |
| 12 |
|
Stoke City | 44 | 17 | 10 | 17 | 55:48 | 7 | 61 |
| 13 |
|
West Bromwich Albion | 44 | 16 | 13 | 15 | 47:45 | 2 | 61 |
| 14 |
|
Swansea City | 44 | 16 | 13 | 15 | 57:62 | -5 | 61 |
| 15 |
|
Blackpool FC | 44 | 16 | 12 | 16 | 54:51 | 3 | 60 |
| 16 |
|
Preston North End | 44 | 14 | 16 | 14 | 45:54 | -9 | 58 |
| 17 |
|
Bristol City | 44 | 14 | 10 | 20 | 57:75 | -18 | 52 |
| 18 |
|
Hull City | 44 | 14 | 8 | 22 | 40:48 | -8 | 50 |
| 19 |
|
Cardiff City | 44 | 14 | 7 | 23 | 48:67 | -19 | 49 |
| 20 |
|
Birmingham City | 44 | 11 | 13 | 20 | 48:72 | -24 | 46 |
| 21 |
|
Reading FC | 44 | 13 | 8 | 23 | 54:85 | -31 | 41 |
| 22 |
|
Peterborough United | 44 | 8 | 10 | 26 | 38:84 | -46 | 34 |
| 23 |
|
Derby County | 44 | 13 | 13 | 18 | 43:52 | -9 | 31 |
| 24 |
|
Barnsley FC | 44 | 6 | 12 | 26 | 32:66 | -34 | 30 |
| Promotie | |
| Play-offs | |
| Degradatie |
