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| U | Sporting Gijón | - | Valencia CF | 2:1 (1:1) | ||
| R | Valencia CF | - | Sporting Gijón | 3:0 (0:0) | ||
| U: 08.01.2019 21:30 | R: 15.01.2019 21:30 | Winnaars: Valencia CF | ||||
| U | Girona FC | - | Atlético Madrid | 1:1 (1:1) | ||
| R | Atlético Madrid | - | Girona FC | 3:3 (1:1) | ||
| U: 09.01.2019 19:30 | R: 16.01.2019 19:30 | Winnaars: Girona FC | ||||
| U | Getafe CF | - | Real Valladolid | 1:0 (0:0) | ||
| R | Real Valladolid | - | Getafe CF | 1:1 (0:1) | ||
| U: 09.01.2019 20:30 | R: 15.01.2019 19:30 | Winnaars: Getafe CF | ||||
| U | Villarreal CF | - | Espanyol | 2:2 (0:1) | ||
| R | Espanyol | - | Villarreal CF | 3:1 (2:1) | ||
| U: 09.01.2019 20:30 | R: 17.01.2019 20:30 | Winnaars: Espanyol | ||||
| U | Real Madrid | - | CD Leganés | 3:0 (1:0) | ||
| R | CD Leganés | - | Real Madrid | 1:0 (1:0) | ||
| U: 09.01.2019 21:30 | R: 16.01.2019 21:30 | Winnaars: Real Madrid | ||||
| U | Athletic Bilbao | - | Sevilla FC | 1:3 (0:1) | ||
| R | Sevilla FC | - | Athletic Bilbao | 0:1 (0:0) | ||
| U: 10.01.2019 19:30 | R: 16.01.2019 20:30 | Winnaars: Sevilla FC | ||||
| U | Real Betis | - | Real Sociedad | 0:0 (0:0) | ||
| R | Real Sociedad | - | Real Betis | 2:2 (1:1) | ||
| U: 10.01.2019 20:30 | R: 17.01.2019 19:30 | Winnaars: Real Betis | ||||
| U | Levante UD | - | FC Barcelona | 2:1 (2:0) | ||
| R | FC Barcelona | - | Levante UD | 3:0 (2:0) | ||
| U: 10.01.2019 21:30 | R: 17.01.2019 21:30 | Winnaars: FC Barcelona | ||||
