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| 25.11.2018 | 11:30 | Rayo Vallecano | - | Sporting de Huelva | 3:1 d.p. | |
| 12:00 | Valencia CF | - | Real Sociedad | 1:2 n.v. | ||
| 12:00 | Real Betis | - | Athletic Bilbao | 3:4 d.p. | ||
| 12:00 | Madrid CFF | - | Fundación Albacete | 1:0 | ||
| 12:30 | EDF Logroño | - | Sevilla FC | 0:1 | ||
| 13:00 | UDG Tenerife Sur | - | Levante UD | 2:3 d.p. | ||
| 15:00 | FC Barcelona | - | Espanyol Barcelona | 2:0 | ||
| 17:45 | Atlético Madrid | - | Málaga CF | 4:2 |
