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| 29.04.2022 | 21:00 | Sevilla FC | - | Cádiz CF | 1:1 (1:0) | |
| 30.04.2022 | 14:00 | Deportivo Alavés | - | Villarreal CF | 2:1 (2:0) | |
| 16:15 | Real Madrid | - | Espanyol | 4:0 (2:0) | ||
| 18:30 | Valencia CF | - | Levante UD | 1:1 (1:0) | ||
| 21:00 | Athletic Bilbao | - | Atlético Madrid | 2:0 (1:0) | ||
| 01.05.2022 | 14:00 | Elche CF | - | CA Osasuna | 1:1 (0:0) | |
| 16:15 | Granada CF | - | Celta de Vigo | 1:1 (0:0) | ||
| 18:30 | Rayo Vallecano | - | Real Sociedad | 1:1 (0:1) | ||
| 21:00 | FC Barcelona | - | RCD Mallorca | 2:1 (1:0) | ||
| 02.05.2022 | 21:00 | Getafe CF | - | Real Betis | 0:0 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 34 | 25 | 6 | 3 | 73:29 | 44 | 81 |
| 2 |
|
FC Barcelona | 34 | 19 | 9 | 6 | 63:34 | 29 | 66 |
| 3 |
|
Sevilla FC | 34 | 17 | 13 | 4 | 50:28 | 22 | 64 |
| 4 |
|
Atlético Madrid | 34 | 18 | 7 | 9 | 59:41 | 18 | 61 |
| 5 |
|
Real Betis | 34 | 17 | 7 | 10 | 56:38 | 18 | 58 |
| 6 |
|
Real Sociedad | 34 | 15 | 11 | 8 | 33:32 | 1 | 56 |
| 7 |
|
Villarreal CF | 34 | 14 | 10 | 10 | 54:33 | 21 | 52 |
| 8 |
|
Athletic Bilbao | 34 | 13 | 12 | 9 | 41:34 | 7 | 51 |
| 9 |
|
CA Osasuna | 34 | 12 | 9 | 13 | 35:45 | -10 | 45 |
| 10 |
|
Valencia CF | 34 | 10 | 13 | 11 | 45:49 | -4 | 43 |
| 11 |
|
Rayo Vallecano | 34 | 11 | 8 | 15 | 35:39 | -4 | 41 |
| 12 |
|
Celta de Vigo | 34 | 10 | 10 | 14 | 37:38 | -1 | 40 |
| 13 |
|
Elche CF | 34 | 10 | 9 | 15 | 37:45 | -8 | 39 |
| 14 |
|
Espanyol | 34 | 10 | 9 | 15 | 37:49 | -12 | 39 |
| 15 |
|
Getafe CF | 34 | 8 | 12 | 14 | 31:37 | -6 | 36 |
| 16 |
|
RCD Mallorca | 34 | 8 | 8 | 18 | 30:56 | -26 | 32 |
| 17 |
|
Cádiz CF | 34 | 6 | 14 | 14 | 30:47 | -17 | 32 |
| 18 |
|
Granada CF | 34 | 6 | 13 | 15 | 37:57 | -20 | 31 |
| 19 |
|
Deportivo Alavés | 34 | 7 | 7 | 20 | 28:56 | -28 | 28 |
| 20 |
|
Levante UD | 34 | 5 | 11 | 18 | 42:66 | -24 | 26 |
| Champions League | |
| Europa League | |
| Degradatie |
