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| 07.05.2022 | 17:00 | Real Valladolid B | - | CD Badajoz | 1:0 (0:0) | |
| 17:00 | CD Tudelano | - | Racing Santander | 3:0 (3:0) | ||
| 19:00 | Unionistas CF | - | Racing Ferrol | 0:1 (0:0) | ||
| 19:00 | Extremadura UD | - | Deportivo La Coruña | 0:2 Toeg. | ||
| 08.05.2022 | 12:00 | Celta de Vigo B | - | CD Leonesa | 5:3 (4:0) | |
| 12:00 | Rayo Majadahonda | - | UD SS Reyes | 1:0 (0:0) | ||
| 12:00 | CF Talavera | - | SD Logroñés | 1:0 (0:0) | ||
| 17:00 | Athletic Bilbao B | - | CD Calahorra | 1:3 (0:2) | ||
| 17:00 | UD Logroñés | - | Zamora CF | 4:1 (2:1) | ||
| 17:00 | Inter de Madrid | - | Real Unión | 2:0 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Santander | 35 | 23 | 7 | 5 | 57:29 | 28 | 76 |
| 2 |
|
Deportivo La Coruña | 35 | 20 | 8 | 7 | 51:25 | 26 | 68 |
| 3 |
|
Racing Ferrol | 35 | 19 | 8 | 8 | 46:25 | 21 | 65 |
| 4 |
|
Celta de Vigo B | 35 | 17 | 8 | 10 | 58:43 | 15 | 59 |
| 5 |
|
UD Logroñés | 35 | 16 | 8 | 11 | 36:33 | 3 | 56 |
| 6 |
|
CD Badajoz | 35 | 14 | 13 | 8 | 38:26 | 12 | 55 |
| 7 |
|
Rayo Majadahonda | 35 | 16 | 5 | 14 | 44:44 | 0 | 53 |
| 8 |
|
CD Calahorra | 35 | 14 | 10 | 11 | 47:37 | 10 | 52 |
| 9 |
|
Unionistas CF | 35 | 13 | 13 | 9 | 49:36 | 13 | 52 |
| 10 |
|
Real Unión | 35 | 15 | 6 | 14 | 43:43 | 0 | 51 |
| 11 |
|
UD SS Reyes | 35 | 13 | 8 | 14 | 35:39 | -4 | 47 |
| 12 |
|
CD Leonesa | 35 | 11 | 12 | 12 | 54:52 | 2 | 45 |
| 13 |
|
SD Logroñés | 35 | 11 | 11 | 13 | 38:37 | 1 | 44 |
| 14 |
|
Inter de Madrid | 35 | 10 | 12 | 13 | 42:47 | -5 | 42 |
| 15 |
|
Athletic Bilbao B | 35 | 10 | 11 | 14 | 33:42 | -9 | 41 |
| 16 |
|
CF Talavera | 35 | 10 | 9 | 16 | 36:45 | -9 | 39 |
| 17 |
|
Real Valladolid B | 35 | 9 | 9 | 17 | 42:57 | -15 | 36 |
| 18 |
|
Zamora CF | 35 | 7 | 10 | 18 | 24:45 | -21 | 31 |
| 19 |
|
CD Tudelano | 35 | 7 | 7 | 21 | 29:45 | -16 | 28 |
| 20 |
|
Extremadura UD | 35 | 5 | 5 | 25 | 22:74 | -52 | 0 |
| Promotie | |
| Play-offs | |
| Degradatie |
