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| 29.10.2021 | 21:00 | Real Sociedad B | - | UD Las Palmas | 0:1 (0:1) | |
| 21:00 | UD Almería | - | CD Leganés | 1:0 (1:0) | ||
| 30.10.2021 | 16:00 | SD Huesca | - | SD Amorebieta | 1:1 (1:0) | |
| 18:15 | CD Lugo | - | Sporting Gijón | 1:1 (0:0) | ||
| 21:00 | FC Cartagena | - | SD Ponferradina | 0:1 (0:1) | ||
| 31.10.2021 | 14:00 | CF Fuenlabrada | - | Girona FC | 1:2 (0:0) | |
| 16:00 | Real Oviedo | - | Málaga CF | 2:1 (1:0) | ||
| 18:15 | Real Valladolid | - | SD Eibar | 2:0 (0:0) | ||
| 20:30 | Real Zaragoza | - | CD Mirandés | 1:1 (1:0) | ||
| 01.11.2021 | 16:00 | AD Alcorcón | - | UD Ibiza | 0:2 (0:0) | |
| 18:15 | CD Tenerife | - | Burgos CF | 4:0 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 13 | 9 | 1 | 3 | 26:11 | 15 | 28 |
| 2 |
|
SD Eibar | 13 | 7 | 3 | 3 | 19:16 | 3 | 24 |
| 3 |
|
CD Tenerife | 13 | 7 | 2 | 4 | 19:12 | 7 | 23 |
| 4 |
|
UD Las Palmas | 13 | 6 | 5 | 2 | 19:13 | 6 | 23 |
| 5 |
|
SD Ponferradina | 13 | 6 | 4 | 3 | 16:11 | 5 | 22 |
| 6 |
|
Sporting Gijón | 13 | 6 | 4 | 3 | 16:13 | 3 | 22 |
| 7 |
|
Real Valladolid | 13 | 6 | 4 | 3 | 17:12 | 5 | 22 |
| 8 |
|
Real Oviedo | 13 | 4 | 7 | 2 | 15:13 | 2 | 19 |
| 9 |
|
UD Ibiza | 13 | 4 | 6 | 3 | 17:18 | -1 | 18 |
| 10 |
|
FC Cartagena | 13 | 6 | 0 | 7 | 17:20 | -3 | 18 |
| 11 |
|
Málaga CF | 13 | 4 | 5 | 4 | 11:14 | -3 | 17 |
| 12 |
|
CD Lugo | 13 | 3 | 7 | 3 | 14:14 | 0 | 16 |
| 13 |
|
Burgos CF | 13 | 4 | 4 | 5 | 13:14 | -1 | 16 |
| 14 |
|
SD Huesca | 13 | 4 | 4 | 5 | 16:14 | 2 | 16 |
| 15 |
|
CF Fuenlabrada | 13 | 3 | 6 | 4 | 11:12 | -1 | 15 |
| 16 |
|
CD Mirandés | 13 | 4 | 3 | 6 | 19:21 | -2 | 15 |
| 17 |
|
Girona FC | 13 | 4 | 3 | 6 | 12:15 | -3 | 15 |
| 18 |
|
Real Sociedad B | 13 | 3 | 5 | 5 | 13:15 | -2 | 14 |
| 19 |
|
Real Zaragoza | 13 | 1 | 10 | 2 | 9:11 | -2 | 13 |
| 20 |
|
CD Leganés | 13 | 2 | 4 | 7 | 12:18 | -6 | 10 |
| 21 |
|
SD Amorebieta | 13 | 1 | 6 | 6 | 12:19 | -7 | 9 |
| 22 |
|
AD Alcorcón | 13 | 2 | 1 | 10 | 9:26 | -17 | 7 |
| Promotie | |
| Play-offs | |
| Degradatie |
