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| 02.11.2021 | 19:00 | SD Ponferradina | - | SD Huesca | 1:1 (0:0) | |
| 19:00 | Sporting Gijón | - | UD Almería | 0:1 (0:0) | ||
| 21:15 | CD Leganés | - | FC Cartagena | 1:1 (1:1) | ||
| 03.11.2021 | 19:00 | SD Amorebieta | - | Real Valladolid | 4:1 (3:1) | |
| 19:00 | CD Mirandés | - | CD Lugo | 3:2 (0:1) | ||
| 21:15 | SD Eibar | - | Real Oviedo | 1:0 (0:0) | ||
| 21:15 | UD Las Palmas | - | CF Fuenlabrada | 2:1 (2:0) | ||
| 04.11.2021 | 19:00 | Burgos CF | - | Real Zaragoza | 0:1 (0:0) | |
| 19:00 | Girona FC | - | AD Alcorcón | 3:1 (0:1) | ||
| 21:15 | Málaga CF | - | Real Sociedad B | 2:1 (2:1) | ||
| 21:15 | UD Ibiza | - | CD Tenerife | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 14 | 10 | 1 | 3 | 27:11 | 16 | 31 |
| 2 |
|
SD Eibar | 14 | 8 | 3 | 3 | 20:16 | 4 | 27 |
| 3 |
|
UD Las Palmas | 14 | 7 | 5 | 2 | 21:14 | 7 | 26 |
| 4 |
|
CD Tenerife | 14 | 7 | 3 | 4 | 19:12 | 7 | 24 |
| 5 |
|
SD Ponferradina | 14 | 6 | 5 | 3 | 17:12 | 5 | 23 |
| 6 |
|
Sporting Gijón | 14 | 6 | 4 | 4 | 16:14 | 2 | 22 |
| 7 |
|
Real Valladolid | 14 | 6 | 4 | 4 | 18:16 | 2 | 22 |
| 8 |
|
Málaga CF | 14 | 5 | 5 | 4 | 13:15 | -2 | 20 |
| 9 |
|
UD Ibiza | 14 | 4 | 7 | 3 | 17:18 | -1 | 19 |
| 10 |
|
FC Cartagena | 14 | 6 | 1 | 7 | 18:21 | -3 | 19 |
| 11 |
|
Real Oviedo | 14 | 4 | 7 | 3 | 15:14 | 1 | 19 |
| 12 |
|
CD Mirandés | 14 | 5 | 3 | 6 | 22:23 | -1 | 18 |
| 13 |
|
Girona FC | 14 | 5 | 3 | 6 | 15:16 | -1 | 18 |
| 14 |
|
SD Huesca | 14 | 4 | 5 | 5 | 17:15 | 2 | 17 |
| 15 |
|
CD Lugo | 14 | 3 | 7 | 4 | 16:17 | -1 | 16 |
| 16 |
|
Real Zaragoza | 14 | 2 | 10 | 2 | 10:11 | -1 | 16 |
| 17 |
|
Burgos CF | 14 | 4 | 4 | 6 | 13:15 | -2 | 16 |
| 18 |
|
CF Fuenlabrada | 14 | 3 | 6 | 5 | 12:14 | -2 | 15 |
| 19 |
|
Real Sociedad B | 14 | 3 | 5 | 6 | 14:17 | -3 | 14 |
| 20 |
|
SD Amorebieta | 14 | 2 | 6 | 6 | 16:20 | -4 | 12 |
| 21 |
|
CD Leganés | 14 | 2 | 5 | 7 | 13:19 | -6 | 11 |
| 22 |
|
AD Alcorcón | 14 | 2 | 1 | 11 | 10:29 | -19 | 7 |
| Promotie | |
| Play-offs | |
| Degradatie |
