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| 03.12.2021 | 21:00 | SD Huesca | - | Real Valladolid | 3:2 (2:0) | |
| 04.12.2021 | 18:15 | CF Fuenlabrada | - | UD Almería | 1:1 (0:0) | |
| 05.12.2021 | 14:00 | SD Ponferradina | - | CD Mirandés | 2:1 (1:0) | |
| 16:00 | Málaga CF | - | SD Amorebieta | 1:2 (0:2) | ||
| 18:15 | CD Lugo | - | UD Ibiza | 0:0 (0:0) | ||
| 18:15 | Real Oviedo | - | AD Alcorcón | 3:1 (0:0) | ||
| 18:15 | Real Sociedad B | - | Burgos CF | 0:1 (0:1) | ||
| 20:30 | UD Las Palmas | - | Sporting Gijón | 1:0 (0:0) | ||
| 06.12.2021 | 16:00 | Real Zaragoza | - | SD Eibar | 1:0 (0:0) | |
| 18:15 | FC Cartagena | - | CD Tenerife | 1:1 (0:0) | ||
| 21:00 | Girona FC | - | CD Leganés | 3:0 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 19 | 13 | 3 | 3 | 34:13 | 21 | 42 |
| 2 |
|
SD Ponferradina | 19 | 10 | 5 | 4 | 26:16 | 10 | 35 |
| 3 |
|
SD Eibar | 19 | 10 | 5 | 4 | 28:22 | 6 | 35 |
| 4 |
|
CD Tenerife | 19 | 10 | 4 | 5 | 25:15 | 10 | 34 |
| 5 |
|
Real Valladolid | 19 | 9 | 4 | 6 | 29:23 | 6 | 31 |
| 6 |
|
UD Las Palmas | 19 | 8 | 6 | 5 | 27:24 | 3 | 30 |
| 7 |
|
Real Oviedo | 19 | 6 | 10 | 3 | 22:17 | 5 | 28 |
| 8 |
|
Girona FC | 19 | 8 | 3 | 8 | 25:23 | 2 | 27 |
| 9 |
|
Real Zaragoza | 19 | 5 | 11 | 3 | 17:16 | 1 | 26 |
| 10 |
|
FC Cartagena | 19 | 8 | 2 | 9 | 23:27 | -4 | 26 |
| 11 |
|
Málaga CF | 19 | 7 | 5 | 7 | 18:24 | -6 | 26 |
| 12 |
|
Burgos CF | 19 | 7 | 4 | 8 | 18:18 | 0 | 25 |
| 13 |
|
SD Huesca | 19 | 6 | 7 | 6 | 21:19 | 2 | 25 |
| 14 |
|
UD Ibiza | 19 | 5 | 9 | 5 | 18:20 | -2 | 24 |
| 15 |
|
Sporting Gijón | 19 | 6 | 5 | 8 | 18:23 | -5 | 23 |
| 16 |
|
CD Lugo | 19 | 4 | 10 | 5 | 23:23 | 0 | 22 |
| 17 |
|
CD Leganés | 19 | 5 | 6 | 8 | 21:23 | -2 | 21 |
| 18 |
|
CD Mirandés | 19 | 5 | 5 | 9 | 26:31 | -5 | 20 |
| 19 |
|
CF Fuenlabrada | 19 | 3 | 10 | 6 | 15:20 | -5 | 19 |
| 20 |
|
SD Amorebieta | 19 | 3 | 8 | 8 | 22:29 | -7 | 17 |
| 21 |
|
Real Sociedad B | 19 | 4 | 5 | 10 | 16:23 | -7 | 17 |
| 22 |
|
AD Alcorcón | 19 | 2 | 3 | 14 | 15:38 | -23 | 9 |
| Promotie | |
| Play-offs | |
| Degradatie |
