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| 31.12.2021 | 14:00 | Real Oviedo | - | SD Ponferradina | 2:0 (0:0) | |
| 16:00 | Burgos CF | - | SD Amorebieta | 2:2 (2:1) | ||
| 16:15 | SD Eibar | - | Real Sociedad B | 3:2 (2:0) | ||
| 02.01.2022 | 14:00 | Real Valladolid | - | CD Leganés | 1:0 (1:0) | |
| 14:00 | UD Almería | - | FC Cartagena | 0:1 (0:1) | ||
| 16:00 | Sporting Gijón | - | CD Lugo | 1:1 (0:1) | ||
| 18:15 | CD Mirandés | - | Real Zaragoza | 2:0 (1:0) | ||
| 18:15 | SD Huesca | - | Girona FC | 0:1 (0:0) | ||
| 21:00 | CF Fuenlabrada | - | UD Ibiza | 1:2 (1:1) | ||
| 21:30 | CD Tenerife | - | UD Las Palmas | 0:1 (0:0) | ||
| 03.01.2022 | 21:00 | AD Alcorcón | - | Málaga CF | 0:1 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 22 | 14 | 3 | 5 | 38:16 | 22 | 45 |
| 2 |
|
SD Eibar | 22 | 12 | 6 | 4 | 34:26 | 8 | 42 |
| 3 |
|
Real Valladolid | 22 | 12 | 4 | 6 | 34:24 | 10 | 40 |
| 4 |
|
CD Tenerife | 22 | 11 | 5 | 6 | 28:17 | 11 | 38 |
| 5 |
|
SD Ponferradina | 22 | 10 | 7 | 5 | 28:20 | 8 | 37 |
| 6 |
|
UD Las Palmas | 22 | 9 | 7 | 6 | 29:26 | 3 | 34 |
| 7 |
|
Girona FC | 22 | 10 | 4 | 8 | 30:25 | 5 | 34 |
| 8 |
|
FC Cartagena | 22 | 10 | 3 | 9 | 28:28 | 0 | 33 |
| 9 |
|
Real Oviedo | 22 | 7 | 11 | 4 | 25:19 | 6 | 32 |
| 10 |
|
Málaga CF | 22 | 8 | 6 | 8 | 21:28 | -7 | 30 |
| 11 |
|
Burgos CF | 22 | 8 | 5 | 9 | 23:23 | 0 | 29 |
| 12 |
|
Sporting Gijón | 22 | 7 | 7 | 8 | 22:25 | -3 | 28 |
| 13 |
|
UD Ibiza | 22 | 6 | 10 | 6 | 21:24 | -3 | 28 |
| 14 |
|
CD Lugo | 22 | 5 | 12 | 5 | 27:26 | 1 | 27 |
| 15 |
|
SD Huesca | 22 | 6 | 9 | 7 | 22:21 | 1 | 27 |
| 16 |
|
CD Mirandés | 22 | 7 | 5 | 10 | 30:34 | -4 | 26 |
| 17 |
|
Real Zaragoza | 22 | 5 | 11 | 6 | 17:23 | -6 | 26 |
| 18 |
|
CD Leganés | 22 | 6 | 7 | 9 | 24:25 | -1 | 25 |
| 19 |
|
SD Amorebieta | 22 | 3 | 11 | 8 | 26:33 | -7 | 20 |
| 20 |
|
CF Fuenlabrada | 22 | 3 | 11 | 8 | 16:24 | -8 | 20 |
| 21 |
|
Real Sociedad B | 22 | 4 | 5 | 13 | 18:30 | -12 | 17 |
| 22 |
|
AD Alcorcón | 22 | 2 | 5 | 15 | 16:40 | -24 | 11 |
| Promotie | |
| Play-offs | |
| Degradatie |
