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| 24.09.2021 | 20:00 | Real Sociedad B | - | SD Huesca | 0:2 (0:1) | |
| 21:00 | UD Almería | - | CD Tenerife | 3:1 (0:0) | ||
| 25.09.2021 | 16:00 | UD Ibiza | - | Burgos CF | 2:0 (1:0) | |
| 18:15 | SD Amorebieta | - | SD Eibar | 1:1 (1:1) | ||
| 18:15 | UD Las Palmas | - | SD Ponferradina | 2:1 (2:0) | ||
| 26.09.2021 | 14:00 | CD Mirandés | - | CD Leganés | 1:2 (1:1) | |
| 16:00 | Sporting Gijón | - | Málaga CF | 2:1 (0:1) | ||
| 18:15 | Real Oviedo | - | Girona FC | 0:0 (0:0) | ||
| 20:30 | CD Lugo | - | Real Zaragoza | 1:1 (1:1) | ||
| 21:00 | Real Valladolid | - | AD Alcorcón | 2:0 (1:0) | ||
| 27.09.2021 | 21:00 | CF Fuenlabrada | - | FC Cartagena | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sporting Gijón | 7 | 5 | 1 | 1 | 11:7 | 4 | 16 |
| 2 |
|
SD Ponferradina | 7 | 5 | 0 | 2 | 10:5 | 5 | 15 |
| 3 |
|
UD Almería | 7 | 5 | 0 | 2 | 15:6 | 9 | 15 |
| 4 |
|
UD Ibiza | 7 | 2 | 5 | 0 | 9:6 | 3 | 11 |
| 5 |
|
CD Tenerife | 7 | 3 | 2 | 2 | 8:6 | 2 | 11 |
| 6 |
|
SD Eibar | 7 | 3 | 2 | 2 | 9:9 | 0 | 11 |
| 7 |
|
CF Fuenlabrada | 7 | 2 | 4 | 1 | 7:5 | 2 | 10 |
| 8 |
|
CD Mirandés | 7 | 3 | 1 | 3 | 11:10 | 1 | 10 |
| 9 |
|
UD Las Palmas | 7 | 2 | 4 | 1 | 8:8 | 0 | 10 |
| 10 |
|
Real Valladolid | 7 | 3 | 1 | 3 | 7:7 | 0 | 10 |
| 11 |
|
Real Oviedo | 7 | 2 | 4 | 1 | 8:6 | 2 | 10 |
| 12 |
|
SD Huesca | 7 | 3 | 1 | 3 | 10:7 | 3 | 10 |
| 13 |
|
FC Cartagena | 7 | 3 | 0 | 4 | 6:10 | -4 | 9 |
| 14 |
|
CD Leganés | 7 | 2 | 2 | 3 | 6:7 | -1 | 8 |
| 15 |
|
Málaga CF | 7 | 2 | 2 | 3 | 6:10 | -4 | 8 |
| 16 |
|
Girona FC | 7 | 2 | 2 | 3 | 5:6 | -1 | 8 |
| 17 |
|
CD Lugo | 7 | 1 | 4 | 2 | 8:10 | -2 | 7 |
| 18 |
|
Real Zaragoza | 7 | 1 | 4 | 2 | 5:7 | -2 | 7 |
| 19 |
|
Real Sociedad B | 7 | 1 | 3 | 3 | 4:7 | -3 | 6 |
| 20 |
|
SD Amorebieta | 7 | 1 | 3 | 3 | 6:10 | -4 | 6 |
| 21 |
|
Burgos CF | 7 | 1 | 3 | 3 | 5:6 | -1 | 6 |
| 22 |
|
AD Alcorcón | 7 | 1 | 0 | 6 | 4:13 | -9 | 3 |
| Promotie | |
| Play-offs | |
| Degradatie |
