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| 08.10.2021 | 21:00 | Real Valladolid | - | Málaga CF | 1:1 (0:1) | |
| 09.10.2021 | 16:00 | CD Lugo | - | Girona FC | 1:0 (0:0) | |
| 16:00 | CD Mirandés | - | SD Eibar | 3:3 (1:2) | ||
| 18:15 | UD Almería | - | UD Las Palmas | 1:1 (1:0) | ||
| 21:00 | Real Oviedo | - | Sporting Gijón | 1:1 (1:0) | ||
| 10.10.2021 | 14:00 | Real Sociedad B | - | SD Ponferradina | 1:1 (0:0) | |
| 16:00 | FC Cartagena | - | UD Ibiza | 5:1 (3:0) | ||
| 18:15 | AD Alcorcón | - | Burgos CF | 1:0 (0:0) | ||
| 18:15 | CD Tenerife | - | SD Amorebieta | 2:1 (1:0) | ||
| 18:15 | CF Fuenlabrada | - | CD Leganés | 2:1 (1:1) | ||
| 11.10.2021 | 21:00 | Real Zaragoza | - | SD Huesca | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 9 | 6 | 1 | 2 | 18:8 | 10 | 19 |
| 2 |
|
Sporting Gijón | 9 | 5 | 3 | 1 | 13:9 | 4 | 18 |
| 3 |
|
SD Ponferradina | 9 | 5 | 2 | 2 | 13:8 | 5 | 17 |
| 4 |
|
CD Tenerife | 9 | 5 | 2 | 2 | 12:8 | 4 | 17 |
| 5 |
|
SD Eibar | 9 | 4 | 3 | 2 | 15:13 | 2 | 15 |
| 6 |
|
UD Las Palmas | 9 | 3 | 5 | 1 | 13:10 | 3 | 14 |
| 7 |
|
CF Fuenlabrada | 9 | 3 | 4 | 2 | 9:7 | 2 | 13 |
| 8 |
|
FC Cartagena | 9 | 4 | 0 | 5 | 12:15 | -3 | 12 |
| 9 |
|
Málaga CF | 9 | 3 | 3 | 3 | 8:11 | -3 | 12 |
| 10 |
|
Real Valladolid | 9 | 3 | 3 | 3 | 10:10 | 0 | 12 |
| 11 |
|
Real Oviedo | 9 | 2 | 6 | 1 | 9:7 | 2 | 12 |
| 12 |
|
CD Mirandés | 9 | 3 | 2 | 4 | 14:14 | 0 | 11 |
| 13 |
|
CD Lugo | 9 | 2 | 5 | 2 | 10:11 | -1 | 11 |
| 14 |
|
UD Ibiza | 9 | 2 | 5 | 2 | 11:14 | -3 | 11 |
| 15 |
|
SD Huesca | 9 | 3 | 2 | 4 | 11:9 | 2 | 11 |
| 16 |
|
Real Sociedad B | 9 | 2 | 4 | 3 | 9:9 | 0 | 10 |
| 17 |
|
CD Leganés | 9 | 2 | 3 | 4 | 8:10 | -2 | 9 |
| 18 |
|
Real Zaragoza | 9 | 1 | 6 | 2 | 5:7 | -2 | 9 |
| 19 |
|
Burgos CF | 9 | 2 | 3 | 4 | 6:7 | -1 | 9 |
| 20 |
|
Girona FC | 9 | 2 | 2 | 5 | 6:9 | -3 | 8 |
| 21 |
|
SD Amorebieta | 9 | 1 | 4 | 4 | 8:13 | -5 | 7 |
| 22 |
|
AD Alcorcón | 9 | 2 | 0 | 7 | 6:17 | -11 | 6 |
| Promotie | |
| Play-offs | |
| Degradatie |
