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| U | Feyenoord | - | Slavia Praag | 3:3 (1:1) | ||
| R | Slavia Praag | - | Feyenoord | 1:3 (1:1) | ||
| U: 07.04.2022 18:45 | R: 14.04.2022 21:00 | Winnaars: Feyenoord | ||||
| U | FK Bodø/Glimt | - | AS Roma | 2:1 (0:1) | ||
| R | AS Roma | - | FK Bodø/Glimt | 4:0 (3:0) | ||
| U: 07.04.2022 21:00 | R: 14.04.2022 21:00 | Winnaars: AS Roma | ||||
| U | Olympique Marseille | - | PAOK Saloniki | 2:1 (2:0) | ||
| R | PAOK Saloniki | - | Olympique Marseille | 0:1 (0:1) | ||
| U: 07.04.2022 21:00 | R: 14.04.2022 21:00 | Winnaars: Olympique Marseille | ||||
| U | Leicester City | - | PSV | 0:0 (0:0) | ||
| R | PSV | - | Leicester City | 1:2 (1:0) | ||
| U: 07.04.2022 21:00 | R: 14.04.2022 18:45 | Winnaars: Leicester City | ||||
