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| U | Lazio Roma | - | AZ Alkmaar | 1:2 (1:1) | ||
| R | AZ Alkmaar | - | Lazio Roma | 2:1 (1:1) | ||
| U: 07.03.2023 18:45 | R: 16.03.2023 21:00 | Winnaars: AZ Alkmaar | ||||
| U | AEK Larnaca | - | West Ham United | 0:2 (0:2) | ||
| R | West Ham United | - | AEK Larnaca | 4:0 (1:0) | ||
| U: 09.03.2023 18:45 | R: 16.03.2023 21:00 | Winnaars: West Ham United | ||||
| U | FC Sheriff | - | OGC Nice | 0:1 (0:1) | ||
| R | OGC Nice | - | FC Sheriff | 3:1 (1:0) | ||
| U: 09.03.2023 18:45 | R: 16.03.2023 21:00 | Winnaars: OGC Nice | ||||
| U | RSC Anderlecht | - | Villarreal CF | 1:1 (0:1) | ||
| R | Villarreal CF | - | RSC Anderlecht | 0:1 (0:0) | ||
| U: 09.03.2023 18:45 | R: 16.03.2023 21:00 | Winnaars: RSC Anderlecht | ||||
| U | ACF Fiorentina | - | Sivasspor | 1:0 (0:0) | ||
| R | Sivasspor | - | ACF Fiorentina | 1:4 (1:1) | ||
| U: 09.03.2023 21:00 | R: 16.03.2023 18:45 | Winnaars: ACF Fiorentina | ||||
| U | Lech Poznań | - | Djurgårdens IF | 2:0 (1:0) | ||
| R | Djurgårdens IF | - | Lech Poznań | 0:3 (0:0) | ||
| U: 09.03.2023 21:00 | R: 16.03.2023 18:45 | Winnaars: Lech Poznań | ||||
| U | FC Basel | - | Slovan Bratislava | 2:2 (2:1) | ||
| R | Slovan Bratislava | - | FC Basel | 1:4 (2:0, 2:2, 2:2) d.p. | ||
| U: 09.03.2023 21:00 | R: 16.03.2023 18:45 | Winnaars: FC Basel | ||||
| U | KAA Gent | - | İstanbul Başakşehir | 1:1 (1:1) | ||
| R | İstanbul Başakşehir | - | KAA Gent | 1:4 (0:4) | ||
| U: 09.03.2023 21:00 | R: 15.03.2023 18:00 | Winnaars: KAA Gent | ||||
