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| U | Zenit St. Petersburg | - | Torino FC | 2:0 (1:0) | ||
| R | Torino FC | - | Zenit St. Petersburg | 1:0 (0:0) | ||
| U: 12.03.2015 18:00 | R: 19.03.2015 21:05 | Winnaars: Zenit St. Petersburg | ||||
| U | Dnipro Dnipropetrovsk | - | AFC Ajax | 1:0 (1:0) | ||
| R | AFC Ajax | - | Dnipro Dnipropetrovsk | 2:1 (0:0, 1:0) n.v. | ||
| U: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Winnaars: Dnipro Dnipropetrovsk | ||||
| U | VfL Wolfsburg | - | Inter | 3:1 (1:1) | ||
| R | Inter | - | VfL Wolfsburg | 1:2 (0:1) | ||
| U: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Winnaars: VfL Wolfsburg | ||||
| U | Club Brugge KV | - | Beşiktaş | 2:1 (0:0) | ||
| R | Beşiktaş | - | Club Brugge KV | 1:3 (0:0) | ||
| U: 12.03.2015 19:00 | R: 19.03.2015 21:05 | Winnaars: Club Brugge KV | ||||
| U | Everton FC | - | Dinamo Kiev | 2:1 (1:1) | ||
| R | Dinamo Kiev | - | Everton FC | 5:2 (3:1) | ||
| U: 12.03.2015 21:05 | R: 19.03.2015 19:00 | Winnaars: Dinamo Kiev | ||||
| U | Villarreal CF | - | Sevilla FC | 1:3 (0:2) | ||
| R | Sevilla FC | - | Villarreal CF | 2:1 (0:0) | ||
| U: 12.03.2015 21:05 | R: 19.03.2015 21:05 | Winnaars: Sevilla FC | ||||
| U | SSC Napoli | - | Dinamo Moskou | 3:1 (2:1) | ||
| R | Dinamo Moskou | - | SSC Napoli | 0:0 (0:0) | ||
| U: 12.03.2015 21:05 | R: 19.03.2015 18:00 | Winnaars: SSC Napoli | ||||
| U | ACF Fiorentina | - | AS Roma | 1:1 (1:0) | ||
| R | AS Roma | - | ACF Fiorentina | 0:3 (0:3) | ||
| U: 12.03.2015 21:05 | R: 19.03.2015 19:00 | Winnaars: ACF Fiorentina | ||||
