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| U | BSC Young Boys | - | Everton FC | 1:4 (1:3) | ||
| R | Everton FC | - | BSC Young Boys | 3:1 (3:1) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: Everton FC | ||||
| U | Torino FC | - | Athletic Bilbao | 2:2 (2:1) | ||
| R | Athletic Bilbao | - | Torino FC | 2:3 (1:2) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: Torino FC | ||||
| U | VfL Wolfsburg | - | Sporting CP | 2:0 (0:0) | ||
| R | Sporting CP | - | VfL Wolfsburg | 0:0 (0:0) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: VfL Wolfsburg | ||||
| U | Aalborg BK | - | Club Brugge KV | 1:3 (0:2) | ||
| R | Club Brugge KV | - | Aalborg BK | 3:0 (1:0) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: Club Brugge KV | ||||
| U | Dnipro Dnipropetrovsk | - | Olympiakos | 2:0 (0:0) | ||
| R | Olympiakos | - | Dnipro Dnipropetrovsk | 2:2 (1:1) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: Dnipro Dnipropetrovsk | ||||
| U | Trabzonspor | - | SSC Napoli | 0:4 (0:3) | ||
| R | SSC Napoli | - | Trabzonspor | 1:0 (1:0) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: SSC Napoli | ||||
| U | AS Roma | - | Feyenoord | 1:1 (1:0) | ||
| R | Feyenoord | - | AS Roma | 1:2 (0:1) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 21:05 | Winnaars: AS Roma | ||||
| U | PSV | - | Zenit St. Petersburg | 0:1 (0:0) | ||
| R | Zenit St. Petersburg | - | PSV | 3:0 (1:0) | ||
| U: 19.02.2015 19:00 | R: 26.02.2015 18:00 | Winnaars: Zenit St. Petersburg | ||||
| U | Sevilla FC | - | Bor. Mönchengladbach | 1:0 (0:0) | ||
| R | Bor. Mönchengladbach | - | Sevilla FC | 2:3 (2:2) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: Sevilla FC | ||||
| U | AFC Ajax | - | Legia Warschau | 1:0 (1:0) | ||
| R | Legia Warschau | - | AFC Ajax | 0:3 (0:3) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: AFC Ajax | ||||
| U | RSC Anderlecht | - | Dinamo Moskou | 0:0 (0:0) | ||
| R | Dinamo Moskou | - | RSC Anderlecht | 3:1 (0:1) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 18:00 | Winnaars: Dinamo Moskou | ||||
| U | EA Guingamp | - | Dinamo Kiev | 2:1 (0:1) | ||
| R | Dinamo Kiev | - | EA Guingamp | 3:1 (1:0) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: Dinamo Kiev | ||||
| U | Villarreal CF | - | RB Salzburg | 2:1 (1:0) | ||
| R | RB Salzburg | - | Villarreal CF | 1:3 (1:1) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: Villarreal CF | ||||
| U | Liverpool FC | - | Beşiktaş | 1:0 (0:0) | ||
| R | Beşiktaş | - | Liverpool FC | 5:4 (0:0, 1:0, 1:0) d.p. | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: Beşiktaş | ||||
| U | Tottenham Hotspur | - | ACF Fiorentina | 1:1 (1:1) | ||
| R | ACF Fiorentina | - | Tottenham Hotspur | 2:0 (0:0) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: ACF Fiorentina | ||||
| U | Celtic FC | - | Inter | 3:3 (2:3) | ||
| R | Inter | - | Celtic FC | 1:0 (0:0) | ||
| U: 19.02.2015 21:05 | R: 26.02.2015 19:00 | Winnaars: Inter | ||||
