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| U | Eintracht Frankfurt | - | Inter | 0:0 (0:0) | ||
| R | Inter | - | Eintracht Frankfurt | 0:1 (0:1) | ||
| U: 07.03.2019 18:55 | R: 14.03.2019 21:00 | Winnaars: Eintracht Frankfurt | ||||
| U | Dinamo Zagreb | - | SL Benfica | 1:0 (1:0) | ||
| R | SL Benfica | - | Dinamo Zagreb | 3:0 (0:0, 1:0) n.v. | ||
| U: 07.03.2019 18:55 | R: 14.03.2019 21:00 | Winnaars: SL Benfica | ||||
| U | Sevilla FC | - | Slavia Praag | 2:2 (2:2) | ||
| R | Slavia Praag | - | Sevilla FC | 4:3 (1:1, 2:2) n.v. | ||
| U: 07.03.2019 18:55 | R: 14.03.2019 21:00 | Winnaars: Slavia Praag | ||||
| U | Stade Rennais | - | Arsenal FC | 3:1 (1:1) | ||
| R | Arsenal FC | - | Stade Rennais | 3:0 (2:0) | ||
| U: 07.03.2019 18:55 | R: 14.03.2019 21:00 | Winnaars: Arsenal FC | ||||
| U | Zenit St. Petersburg | - | Villarreal CF | 1:3 (1:1) | ||
| R | Villarreal CF | - | Zenit St. Petersburg | 2:1 (1:0) | ||
| U: 07.03.2019 18:55 | R: 14.03.2019 21:00 | Winnaars: Villarreal CF | ||||
| U | Chelsea FC | - | Dinamo Kiev | 3:0 (1:0) | ||
| R | Dinamo Kiev | - | Chelsea FC | 0:5 (0:3) | ||
| U: 07.03.2019 21:00 | R: 14.03.2019 18:55 | Winnaars: Chelsea FC | ||||
| U | SSC Napoli | - | RB Salzburg | 3:0 (2:0) | ||
| R | RB Salzburg | - | SSC Napoli | 3:1 (1:1) | ||
| U: 07.03.2019 21:00 | R: 14.03.2019 18:55 | Winnaars: SSC Napoli | ||||
| U | Valencia CF | - | FK Krasnodar | 2:1 (2:0) | ||
| R | FK Krasnodar | - | Valencia CF | 1:1 (0:0) | ||
| U: 07.03.2019 21:00 | R: 14.03.2019 18:55 | Winnaars: Valencia CF | ||||
