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| 12.02.2022 | 17:00 | Canet Roussillon | - | Angers SCO II | 2:0 (1:0) | |
| 18:00 | Angoulême CFC | - | Le Puy Foot 43 | 1:0 (0:0) | ||
| 18:00 | AS Béziers | - | Bergerac Foot | 1:1 (0:0) | ||
| 18:00 | Andrézieux-Bouthéon FC | - | FC Chamalières | 0:0 (0:0) | ||
| 18:00 | Trélissac FC | - | Bourges Foot 18 | 1:2 (0:1) | ||
| 18:00 | US Colomiers | - | Montpellier HSC (CFA) | 1:1 (1:0) | ||
| 18:00 | Moulins Yzeure Foot | - | Stade Montois | 2:0 (0:0) | ||
| 26.02.2022 | 18:00 | FC Nantes (CFA) | - | Vendée Les Herbiers | 1:3 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bergerac Foot | 18 | 10 | 6 | 2 | 23:10 | 13 | 36 |
| 2 |
|
Angoulême CFC | 18 | 10 | 5 | 3 | 26:15 | 11 | 35 |
| 3 |
|
Moulins Yzeure Foot | 18 | 8 | 7 | 3 | 19:13 | 6 | 31 |
| 4 |
|
Bourges Foot 18 | 18 | 9 | 3 | 6 | 26:16 | 10 | 30 |
| 5 |
|
Andrézieux-Bouthéon FC | 18 | 9 | 3 | 6 | 23:16 | 7 | 30 |
| 6 |
|
Le Puy Foot 43 | 18 | 8 | 5 | 5 | 22:12 | 10 | 29 |
| 7 |
|
AS Béziers | 18 | 8 | 5 | 5 | 24:18 | 6 | 29 |
| 8 |
|
FC Nantes (CFA) | 18 | 6 | 7 | 5 | 23:19 | 4 | 25 |
| 9 |
|
Vendée Les Herbiers | 18 | 6 | 6 | 6 | 23:25 | -2 | 24 |
| 10 |
|
Trélissac FC | 18 | 6 | 4 | 8 | 15:16 | -1 | 22 |
| 11 |
|
Angers SCO II | 18 | 5 | 6 | 7 | 19:20 | -1 | 21 |
| 12 |
|
FC Chamalières | 18 | 5 | 4 | 9 | 21:27 | -6 | 19 |
| 13 |
|
US Colomiers | 18 | 4 | 7 | 7 | 16:22 | -6 | 19 |
| 14 |
|
Canet Roussillon | 18 | 8 | 4 | 6 | 17:22 | -5 | 17 |
| 15 |
|
Montpellier HSC (CFA) | 18 | 4 | 3 | 11 | 18:29 | -11 | 15 |
| 16 |
|
Stade Montois | 18 | 0 | 1 | 17 | 12:47 | -35 | 1 |
| Promotie | |
| Degradatie |
