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| 05.11.2021 | 19:00 | FC Bastia-Borgo | - | SO Cholet | 1:2 (1:0) | |
| 19:00 | FC Annecy | - | Le Mans FC | 1:1 (0:0) | ||
| 19:00 | FC Chambly | - | FC Sète | 1:4 (1:2) | ||
| 19:00 | Red Star FC | - | LB Châteauroux | 0:2 (0:1) | ||
| 19:00 | FC Villefranche Beaujolais | - | US Avranches | 3:0 (2:0) | ||
| 19:00 | Stade Lavallois | - | Stade Briochin | 2:0 (1:0) | ||
| 19:00 | US Boulogne | - | FC Bourg-Péronnas | 1:2 (1:1) | ||
| 19:00 | US Orléans | - | US Créteil-Lusitanos | 2:1 (1:0) | ||
| 08.11.2021 | 20:45 | US Concarneau | - | CS Sedan | 1:1 (1:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Bourg-Péronnas | 13 | 8 | 4 | 1 | 29:11 | 18 | 28 |
| 2 |
|
FC Annecy | 13 | 8 | 3 | 2 | 24:10 | 14 | 27 |
| 3 |
|
FC Villefranche Beaujolais | 13 | 7 | 5 | 1 | 17:8 | 9 | 26 |
| 4 |
|
US Concarneau | 13 | 7 | 4 | 2 | 19:12 | 7 | 25 |
| 5 |
|
Stade Lavallois | 13 | 7 | 2 | 4 | 15:11 | 4 | 23 |
| 6 |
|
LB Châteauroux | 13 | 6 | 4 | 3 | 15:12 | 3 | 22 |
| 7 |
|
CS Sedan | 13 | 5 | 6 | 2 | 12:7 | 5 | 21 |
| 8 |
|
Le Mans FC | 13 | 5 | 5 | 3 | 15:11 | 4 | 20 |
| 9 |
|
SO Cholet | 13 | 6 | 1 | 6 | 24:27 | -3 | 19 |
| 10 |
|
US Avranches | 13 | 5 | 2 | 6 | 13:22 | -9 | 17 |
| 11 |
|
US Orléans | 13 | 3 | 5 | 5 | 13:13 | 0 | 14 |
| 12 |
|
FC Chambly | 13 | 4 | 2 | 7 | 16:21 | -5 | 14 |
| 13 |
|
FC Sète | 13 | 4 | 1 | 8 | 17:20 | -3 | 13 |
| 14 |
|
Stade Briochin | 13 | 3 | 4 | 6 | 9:12 | -3 | 13 |
| 15 |
|
Red Star FC | 13 | 4 | 1 | 8 | 18:24 | -6 | 12 |
| 16 |
|
US Créteil-Lusitanos | 13 | 2 | 4 | 7 | 9:22 | -13 | 10 |
| 17 |
|
US Boulogne | 13 | 2 | 4 | 7 | 14:20 | -6 | 9 |
| 18 |
|
FC Bastia-Borgo | 13 | 0 | 5 | 8 | 12:28 | -16 | 5 |
| Promotie | |
| Promotie en degradatie | |
| Degradatie |
