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| 23.04.2022 | 11:00 | Eintracht Frankfurt II | - | Bayern München II | 3:1 (1:1) | |
| 24.04.2022 | 11:00 | SV 07 Elversberg | - | RB Leipzig | 0:3 (0:0) | |
| 11:00 | FC Ingolstadt 04 | - | SV Henstedt-Ulzburg | 2:2 (1:1) | ||
| 11:00 | FSV Gütersloh 2009 | - | 1. FC Nürnberg | 3:4 (3:2) | ||
| 11:00 | SV Meppen | - | 1899 Hoffenheim II | 1:0 (0:0) | ||
| 11:00 | SG 99 Andernach | - | VfL Wolfsburg II | 3:0 (0:0) | ||
| 14:00 | Borussia Bocholt | - | MSV Duisburg | 0:2 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 21 | 15 | 3 | 3 | 52:16 | 36 | 48 |
| 2 |
|
MSV Duisburg | 21 | 14 | 3 | 4 | 41:22 | 19 | 45 |
| 3 |
|
RB Leipzig | 21 | 13 | 2 | 6 | 54:34 | 20 | 41 |
| 4 |
|
1. FC Nürnberg | 21 | 13 | 1 | 7 | 41:30 | 11 | 40 |
| 5 |
|
SG 99 Andernach | 21 | 11 | 4 | 6 | 45:27 | 18 | 37 |
| 6 |
|
Eintracht Frankfurt II | 21 | 9 | 6 | 6 | 40:31 | 9 | 33 |
| 7 |
|
Bayern München II | 21 | 10 | 3 | 8 | 33:36 | -3 | 33 |
| 8 |
|
FSV Gütersloh 2009 | 21 | 8 | 4 | 9 | 38:34 | 4 | 28 |
| 9 |
|
1899 Hoffenheim II | 21 | 6 | 7 | 8 | 23:29 | -6 | 25 |
| 10 |
|
FC Ingolstadt 04 | 21 | 7 | 3 | 11 | 45:43 | 2 | 24 |
| 11 |
|
SV 07 Elversberg | 21 | 5 | 4 | 12 | 19:43 | -24 | 19 |
| 12 |
|
VfL Wolfsburg II | 21 | 4 | 5 | 12 | 15:35 | -20 | 17 |
| 13 |
|
SV Henstedt-Ulzburg | 21 | 4 | 3 | 14 | 29:62 | -33 | 15 |
| 14 |
|
Borussia Bocholt | 21 | 3 | 2 | 16 | 21:54 | -33 | 11 |
| Promotie | |
| Degradatie |
