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| 08.05.2022 | 11:00 | SV Meppen | - | Eintracht Frankfurt II | 2:0 (2:0) | |
| 11:00 | SG 99 Andernach | - | Bayern München II | 2:1 (1:0) | ||
| 11:00 | Borussia Bocholt | - | 1899 Hoffenheim II | 2:1 (1:1) | ||
| 11:00 | SV 07 Elversberg | - | VfL Wolfsburg II | 1:2 (1:1) | ||
| 11:00 | FC Ingolstadt 04 | - | MSV Duisburg | 1:2 (1:0) | ||
| 14:00 | RB Leipzig | - | 1. FC Nürnberg | 2:1 (2:1) | ||
| 14:00 | FSV Gütersloh 2009 | - | SV Henstedt-Ulzburg | 4:1 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 23 | 17 | 3 | 3 | 56:16 | 40 | 54 |
| 2 |
|
MSV Duisburg | 23 | 16 | 3 | 4 | 49:24 | 25 | 51 |
| 3 |
|
RB Leipzig | 23 | 15 | 2 | 6 | 60:38 | 22 | 47 |
| 4 |
|
SG 99 Andernach | 23 | 13 | 4 | 6 | 50:28 | 22 | 43 |
| 5 |
|
1. FC Nürnberg | 23 | 13 | 1 | 9 | 43:35 | 8 | 40 |
| 6 |
|
Eintracht Frankfurt II | 23 | 10 | 6 | 7 | 42:33 | 9 | 36 |
| 7 |
|
Bayern München II | 23 | 10 | 3 | 10 | 34:40 | -6 | 33 |
| 8 |
|
FSV Gütersloh 2009 | 23 | 9 | 4 | 10 | 42:37 | 5 | 31 |
| 9 |
|
1899 Hoffenheim II | 23 | 6 | 7 | 10 | 24:34 | -10 | 25 |
| 10 |
|
FC Ingolstadt 04 | 23 | 7 | 3 | 13 | 49:49 | 0 | 24 |
| 11 |
|
VfL Wolfsburg II | 23 | 6 | 5 | 12 | 18:36 | -18 | 23 |
| 12 |
|
SV 07 Elversberg | 23 | 5 | 4 | 14 | 21:51 | -30 | 19 |
| 13 |
|
SV Henstedt-Ulzburg | 23 | 5 | 3 | 15 | 33:67 | -34 | 18 |
| 14 |
|
Borussia Bocholt | 23 | 4 | 2 | 17 | 23:56 | -33 | 14 |
| Promotie | |
| Degradatie |
