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| 22.05.2022 | 11:00 | Borussia Bocholt | - | Eintracht Frankfurt II | 2:8 (1:3) | |
| 11:00 | SV 07 Elversberg | - | Bayern München II | 1:2 (0:1) | ||
| 11:00 | 1. FC Nürnberg | - | VfL Wolfsburg II | 3:3 (1:3) | ||
| 11:00 | SV Henstedt-Ulzburg | - | MSV Duisburg | 1:3 (0:1) | ||
| 14:00 | RB Leipzig | - | FSV Gütersloh 2009 | 6:1 (0:1) | ||
| 14:00 | SG 99 Andernach | - | SV Meppen | 1:3 (0:1) | ||
| 14:00 | FC Ingolstadt 04 | - | 1899 Hoffenheim II | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SV Meppen | 25 | 18 | 4 | 3 | 61:19 | 42 | 58 |
| 2 |
|
MSV Duisburg | 25 | 18 | 3 | 4 | 53:25 | 28 | 57 |
| 3 |
|
RB Leipzig | 25 | 17 | 2 | 6 | 69:40 | 29 | 53 |
| 4 |
|
SG 99 Andernach | 25 | 13 | 5 | 7 | 53:33 | 20 | 44 |
| 5 |
|
1. FC Nürnberg | 25 | 13 | 2 | 10 | 46:39 | 7 | 41 |
| 6 |
|
Eintracht Frankfurt II | 25 | 11 | 7 | 7 | 52:37 | 15 | 40 |
| 7 |
|
Bayern München II | 25 | 11 | 3 | 11 | 40:46 | -6 | 36 |
| 8 |
|
FSV Gütersloh 2009 | 25 | 9 | 5 | 11 | 45:45 | 0 | 32 |
| 9 |
|
FC Ingolstadt 04 | 25 | 8 | 3 | 14 | 52:54 | -2 | 27 |
| 10 |
|
VfL Wolfsburg II | 25 | 7 | 6 | 12 | 25:40 | -15 | 27 |
| 11 |
|
1899 Hoffenheim II | 25 | 6 | 7 | 12 | 25:38 | -13 | 25 |
| 12 |
|
SV 07 Elversberg | 25 | 6 | 4 | 15 | 24:53 | -29 | 22 |
| 13 |
|
SV Henstedt-Ulzburg | 25 | 5 | 3 | 17 | 35:73 | -38 | 18 |
| 14 |
|
Borussia Bocholt | 25 | 5 | 2 | 18 | 30:68 | -38 | 17 |
| Promotie | |
| Degradatie |
