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| U | Panetolikos | - | Olympiakos | 2:1 (1:1) | ||
| R | Olympiakos | - | Panetolikos | 3:1 (1:0, 2:1) n.v. | ||
| U: 19.01.2022 14:00 | R: 09.02.2022 17:00 | Winnaars: Olympiakos | ||||
| U | Panathinaikos | - | Anagennisi Karditsa | 4:0 (4:0) | ||
| R | Anagennisi Karditsa | - | Panathinaikos | 0:1 (0:0) | ||
| U: 19.01.2022 16:00 | R: 09.02.2022 15:00 | Winnaars: Panathinaikos | ||||
| U | PAOK Saloniki | - | AEK Athene | 0:0 (0:0) | ||
| R | AEK Athene | - | PAOK Saloniki | 1:2 (0:0) | ||
| U: 19.01.2022 18:00 | R: 09.02.2022 19:00 | Winnaars: PAOK Saloniki | ||||
| U | Aris Saloniki | - | Lamia | 0:0 (0:0) | ||
| R | Lamia | - | Aris Saloniki | 1:0 (0:0, 0:0) n.v. | ||
| U: 20.01.2022 20:30 | R: 26.01.2022 19:00 | Winnaars: Lamia | ||||
