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| 27.04.2022 | 14:30 | PAOK Saloniki II | - | AE Lárissa | 2:0 (0:0) | |
| 14:30 | Olympiakos Volou | - | Apollon Lárissa | 2:1 (1:1) | ||
| 14:30 | Niki Volou FC | - | Olympiakos Piraeus II | 0:1 (0:0) | ||
| 14:30 | Almopos Arideas | - | Panserraikos | 0:1 (0:1) | ||
| 14:30 | AO Kavala | - | AEP Iraklis FC | 1:1 (0:0) | ||
| 14:30 | Thesprotos | - | Veria FC | 1:3 (0:3) | ||
| 14:30 | Xanthi FC | - | Apollon Pontou | 2:1 (0:0) | ||
| 14:30 | Pierikos Katerini | - | Anagennisi Karditsa | 2:2 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 31 | 22 | 6 | 3 | 59:22 | 37 | 72 |
| 2 |
|
AE Lárissa | 31 | 18 | 10 | 3 | 39:15 | 24 | 64 |
| 3 |
|
Xanthi FC | 31 | 13 | 14 | 4 | 43:21 | 22 | 53 |
| 4 |
|
Niki Volou FC | 31 | 14 | 9 | 8 | 38:20 | 18 | 51 |
| 5 |
|
Anagennisi Karditsa | 31 | 14 | 6 | 11 | 43:34 | 9 | 48 |
| 6 |
|
Olympiakos Piraeus II | 31 | 13 | 9 | 9 | 37:29 | 8 | 48 |
| 7 |
|
AEP Iraklis FC | 31 | 10 | 15 | 6 | 45:29 | 16 | 45 |
| 8 |
|
PAOK Saloniki II | 31 | 11 | 11 | 9 | 40:30 | 10 | 44 |
| 9 |
|
Almopos Arideas | 31 | 10 | 9 | 12 | 40:33 | 7 | 39 |
| 10 |
|
Apollon Pontou | 31 | 9 | 9 | 13 | 34:38 | -4 | 36 |
| 11 |
|
Thesprotos | 31 | 8 | 9 | 14 | 34:43 | -9 | 33 |
| 12 |
|
Panserraikos | 31 | 7 | 11 | 13 | 31:39 | -8 | 32 |
| 13 |
|
Pierikos Katerini | 32 | 7 | 11 | 14 | 36:49 | -13 | 32 |
| 14 |
|
Apollon Lárissa | 31 | 7 | 11 | 13 | 25:41 | -16 | 32 |
| 15 |
|
AO Kavala | 31 | 7 | 10 | 14 | 24:69 | -45 | 31 |
| 16 |
|
Olympiakos Volou | 31 | 7 | 8 | 16 | 32:46 | -14 | 29 |
| 17 |
|
AO Trikala | 31 | 5 | 6 | 20 | 17:59 | -42 | 21 |
| Play-offs | |
| Degradatie |
