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| 06.11.2021 | 11:00 | Bologna FC | - | Cagliari Calcio | 2:3 (1:2) | |
| 11:00 | Juventus | - | Genoa CFC | 2:1 (1:0) | ||
| 11:00 | Sampdoria | - | Delfino Pescara | 2:0 (1:0) | ||
| 13:00 | SSC Napoli | - | Sassuolo Calcio | 1:1 (0:1) | ||
| 15:00 | ACF Fiorentina | - | Atalanta | 1:0 (0:0) | ||
| 07.11.2021 | 10:45 | Inter | - | AS Roma | 0:1 (0:0) | |
| 11:00 | US Lecce | - | Empoli FC | 0:0 (0:0) | ||
| 12:45 | Hellas Verona | - | AC Milan | 5:1 (3:0) | ||
| 15:00 | SPAL 2013 Ferrara | - | Torino FC | 0:2 (0:2) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Roma | 8 | 6 | 2 | 0 | 18:4 | 14 | 20 |
| 2 |
|
ACF Fiorentina | 8 | 5 | 1 | 2 | 13:8 | 5 | 16 |
| 3 |
|
Juventus | 8 | 5 | 0 | 3 | 13:12 | 1 | 15 |
| 4 |
|
Torino FC | 8 | 4 | 2 | 2 | 13:13 | 0 | 14 |
| 5 |
|
Genoa CFC | 8 | 4 | 1 | 3 | 15:8 | 7 | 13 |
| 6 |
|
Empoli FC | 8 | 3 | 4 | 1 | 13:6 | 7 | 13 |
| 7 |
|
SSC Napoli | 8 | 4 | 1 | 3 | 10:14 | -4 | 13 |
| 8 |
|
Inter | 8 | 3 | 3 | 2 | 14:11 | 3 | 12 |
| 9 |
|
Cagliari Calcio | 8 | 3 | 3 | 2 | 12:12 | 0 | 12 |
| 10 |
|
SPAL 2013 Ferrara | 8 | 3 | 2 | 3 | 6:13 | -7 | 11 |
| 11 |
|
Sampdoria | 8 | 3 | 1 | 4 | 16:11 | 5 | 10 |
| 12 |
|
Hellas Verona | 8 | 3 | 1 | 4 | 9:12 | -3 | 10 |
| 13 |
|
US Lecce | 8 | 1 | 5 | 2 | 8:8 | 0 | 8 |
| 14 |
|
Atalanta | 8 | 2 | 2 | 4 | 12:14 | -2 | 8 |
| 15 |
|
Sassuolo Calcio | 8 | 1 | 4 | 3 | 5:7 | -2 | 7 |
| 16 |
|
Bologna FC | 8 | 2 | 1 | 5 | 11:15 | -4 | 7 |
| 17 |
|
AC Milan | 8 | 1 | 2 | 5 | 7:15 | -8 | 5 |
| 18 |
|
Delfino Pescara | 8 | 1 | 1 | 6 | 7:19 | -12 | 4 |
| Play-offs | |
| Volgende Ronde | |
| Promotie en degradatie | |
| Degradatie |
