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| 05.02.2022 | 14:00 | Benevento Calcio | - | Parma Calcio 1913 | 0:0 (0:0) | |
| 14:00 | Calcio Como | - | US Lecce | 1:1 (1:1) | ||
| 14:00 | FC Crotone | - | AS Cittadella | 0:0 (0:0) | ||
| 14:00 | Ternana Calcio | - | Reggina 1914 | 2:0 (2:0) | ||
| 14:00 | US Alessandria 1912 | - | AC Pisa | 1:1 (1:1) | ||
| 14:00 | Cosenza Calcio | - | Brescia Calcio | 0:0 (0:0) | ||
| 16:15 | Frosinone Calcio | - | Vicenza Virtus | 2:0 (1:0) | ||
| 18:30 | Ascoli Calcio | - | AC Perugia Calcio | 0:1 (0:1) | ||
| 06.02.2022 | 16:15 | Pordenone Calcio | - | SPAL 2013 Ferrara | 1:1 (1:0) | |
| 16:15 | US Cremonese | - | AC Monza | 3:2 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Lecce | 21 | 11 | 8 | 2 | 35:18 | 17 | 41 |
| 2 |
|
AC Pisa | 21 | 11 | 7 | 3 | 28:16 | 12 | 40 |
| 3 |
|
Brescia Calcio | 21 | 11 | 6 | 4 | 33:21 | 12 | 39 |
| 4 |
|
US Cremonese | 21 | 11 | 5 | 5 | 33:21 | 12 | 38 |
| 5 |
|
Frosinone Calcio | 21 | 9 | 10 | 2 | 34:18 | 16 | 37 |
| 6 |
|
Benevento Calcio | 21 | 10 | 6 | 5 | 33:20 | 13 | 36 |
| 7 |
|
AC Monza | 21 | 9 | 8 | 4 | 30:24 | 6 | 35 |
| 8 |
|
AS Cittadella | 21 | 8 | 8 | 5 | 25:22 | 3 | 32 |
| 9 |
|
Ascoli Calcio | 21 | 9 | 5 | 7 | 29:28 | 1 | 32 |
| 10 |
|
AC Perugia Calcio | 21 | 7 | 10 | 4 | 22:19 | 3 | 31 |
| 11 |
|
Calcio Como | 21 | 6 | 9 | 6 | 27:26 | 1 | 27 |
| 12 |
|
Ternana Calcio | 21 | 7 | 6 | 8 | 32:32 | 0 | 27 |
| 13 |
|
Parma Calcio 1913 | 21 | 5 | 10 | 6 | 22:23 | -1 | 25 |
| 14 |
|
SPAL 2013 Ferrara | 21 | 5 | 8 | 8 | 24:28 | -4 | 23 |
| 15 |
|
US Alessandria 1912 | 21 | 6 | 3 | 12 | 23:32 | -9 | 21 |
| 16 |
|
Reggina 1914 | 21 | 6 | 5 | 10 | 16:29 | -13 | 21 |
| 17 |
|
Cosenza Calcio | 21 | 4 | 6 | 11 | 17:33 | -16 | 18 |
| 18 |
|
FC Crotone | 21 | 2 | 8 | 11 | 22:34 | -12 | 14 |
| 19 |
|
Pordenone Calcio | 21 | 2 | 6 | 13 | 17:39 | -22 | 12 |
| 20 |
|
Vicenza Virtus | 21 | 3 | 2 | 16 | 21:40 | -19 | 11 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
