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| 26.09.2021 | 15:00 | ASG Nocerina | - | FC Francavilla | 2:1 | |
| 15:00 | Brindisi | - | US Bitonto | 1:3 | ||
| 15:00 | Casarano | - | Bisceglie | 0:1 | ||
| 15:00 | Città di Fasano | - | Casertana FC | 1:1 | ||
| 15:00 | Sporting Fulgor Molfetta | - | Audace Cerignola | 1:1 | ||
| 15:00 | Rotonda | - | Mariglianese | 0:1 | ||
| 15:00 | San Giorgio-Sedico | - | Lavello | 0:1 | ||
| 15:00 | Sorrento Calcio | - | Virtus Matino | 0:2 | ||
| 15:00 | ASD SS Nola 1925 | - | ACD Nardò | 2:1 | ||
| 19:00 | Team Altamura | - | FBC Gravina | 0:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Bitonto | 2 | 1 | 1 | 0 | 5:3 | 2 | 4 |
| 2 |
|
Audace Cerignola | 2 | 1 | 1 | 0 | 4:2 | 2 | 4 |
| 3 |
|
Virtus Matino | 2 | 1 | 1 | 0 | 3:1 | 2 | 4 |
| 4 |
|
Casertana FC | 2 | 1 | 1 | 0 | 3:2 | 1 | 4 |
| 5 |
|
ASG Nocerina | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
| 6 |
|
Bisceglie | 2 | 1 | 1 | 0 | 1:0 | 1 | 4 |
| 7 |
|
Lavello | 2 | 1 | 1 | 0 | 2:1 | 1 | 4 |
| 8 |
|
ASD SS Nola 1925 | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 |
|
FC Francavilla | 2 | 1 | 0 | 1 | 3:3 | 0 | 3 | |
| 10 |
|
Casarano | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
|
FBC Gravina | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 | |
|
Sorrento Calcio | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 | |
| 13 |
|
Mariglianese | 2 | 1 | 0 | 1 | 1:2 | -1 | 3 |
| 14 |
|
ACD Nardò | 2 | 1 | 0 | 1 | 5:4 | 1 | 3 |
| 15 |
|
Sporting Fulgor Molfetta | 2 | 0 | 2 | 0 | 2:2 | 0 | 2 |
| 16 |
|
San Giorgio-Sedico | 2 | 0 | 1 | 1 | 1:2 | -1 | 1 |
| 17 |
|
Città di Fasano | 2 | 0 | 1 | 1 | 2:4 | -2 | 1 |
| 18 |
|
Brindisi | 2 | 0 | 0 | 2 | 2:5 | -3 | 0 |
|
Team Altamura | 2 | 0 | 0 | 2 | 2:5 | -3 | 0 | |
| 20 |
|
Rotonda | 2 | 0 | 1 | 1 | 2:3 | -1 | -7 |
| Promotie | |
| Play-offs | |
| Promotie en degradatie | |
| Degradatie |
