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| 04.12.2021 | 16:00 | FC Wiltz 71 | - | RM Hamm Benfica | 1:0 (1:0) | |
| 17:00 | F91 Dudelange | - | FC Rodange 91 | 5:1 (2:0) | ||
| 17:00 | Progrès Niedercorn | - | Etzella Ettelbruck | 6:0 (3:0) | ||
| 17:30 | RFCU Luxemburg | - | CS FOLA Esch | 0:1 (0:0) | ||
| 05.12.2021 | 16:00 | US Hostert | - | UNA Strassen | 1:1 (1:1) | |
| 16:00 | Jeunesse Esch | - | Swift Hesperange | 1:0 (0:0) | ||
| 16:00 | US Mondorf | - | FC Differdange 03 | 3:3 (2:3) | ||
| 16:00 | Union Titus Pétange | - | Victoria Rosport | 0:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
F91 Dudelange | 14 | 9 | 3 | 2 | 39:16 | 23 | 30 |
| 2 |
|
Progrès Niedercorn | 14 | 9 | 2 | 3 | 36:15 | 21 | 29 |
| 3 |
|
UNA Strassen | 14 | 8 | 4 | 2 | 25:14 | 11 | 28 |
| 4 |
|
RFCU Luxemburg | 14 | 9 | 0 | 5 | 29:20 | 9 | 27 |
| 5 |
|
CS FOLA Esch | 14 | 7 | 5 | 2 | 24:19 | 5 | 26 |
| 6 |
|
Swift Hesperange | 14 | 7 | 3 | 4 | 27:15 | 12 | 24 |
| 7 |
|
Victoria Rosport | 14 | 7 | 2 | 5 | 29:23 | 6 | 23 |
| 8 |
|
FC Differdange 03 | 14 | 6 | 4 | 4 | 25:19 | 6 | 22 |
| 9 |
|
Union Titus Pétange | 14 | 6 | 0 | 8 | 22:22 | 0 | 18 |
| 10 |
|
Jeunesse Esch | 14 | 5 | 3 | 6 | 16:16 | 0 | 18 |
| 11 |
|
US Hostert | 14 | 5 | 2 | 7 | 25:29 | -4 | 17 |
| 12 |
|
US Mondorf | 14 | 5 | 2 | 7 | 18:22 | -4 | 17 |
| 13 |
|
FC Wiltz 71 | 14 | 5 | 1 | 8 | 19:27 | -8 | 16 |
| 14 |
|
Etzella Ettelbruck | 14 | 5 | 0 | 9 | 23:38 | -15 | 15 |
| 15 |
|
FC Rodange 91 | 14 | 2 | 1 | 11 | 14:34 | -20 | 7 |
| 16 |
|
RM Hamm Benfica | 14 | 1 | 0 | 13 | 7:49 | -42 | 3 |
| Champions League Kwali. | |
| Promotie en degradatie | |
| Degradatie |
