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| 23.04.2022 | 16:30 | Club Necaxa | - | FC Juárez | 1:0 (1:0) | |
| 17:00 | Mazatlán FC | - | Atlético San Luis | 2:0 (0:0) | ||
| 18:30 | Santos Laguna | - | UANL Tigres | 5:0 (3:0) | ||
| 18:30 | Pumas UNAM | - | Deportivo Toluca | 3:1 (2:1) | ||
| 18:30 | Atlas Guadalajara | - | Deportivo Guadalajara | 2:1 (2:1) | ||
| 18:30 | Club León | - | Club Tijuana | 2:1 (1:1) | ||
| 23:00 | Puebla FC | - | Cruz Azul | 0:2 (0:0) | ||
| 24.04.2022 | 18:00 | CF América | - | CF Pachuca | 4:3 (2:2) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 14 | 10 | 4 | 0 | 33:15 | 18 | 34 |
| 2 |
|
CF Pachuca | 14 | 9 | 1 | 4 | 40:19 | 21 | 28 |
| 3 |
|
Club Necaxa | 14 | 8 | 2 | 4 | 30:18 | 12 | 26 |
| 4 |
|
Deportivo Toluca | 15 | 6 | 4 | 5 | 25:24 | 1 | 22 |
| 5 |
|
CF América | 14 | 6 | 2 | 6 | 26:21 | 5 | 20 |
| 6 |
|
FC Juárez | 14 | 6 | 2 | 6 | 20:19 | 1 | 20 |
| 7 |
|
Gallos Blancos | 14 | 4 | 2 | 8 | 13:25 | -12 | 14 |
| 8 |
|
Cruz Azul | 15 | 3 | 2 | 10 | 19:38 | -19 | 11 |
| 9 |
|
Puebla FC | 14 | 2 | 1 | 11 | 8:35 | -27 | 7 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 14 | 10 | 3 | 1 | 32:10 | 22 | 33 |
| 2 |
|
Atlas Guadalajara | 14 | 9 | 2 | 3 | 35:16 | 19 | 29 |
| 3 |
|
UANL Tigres | 14 | 9 | 1 | 4 | 28:22 | 6 | 28 |
| 4 |
|
Santos Laguna | 14 | 7 | 3 | 4 | 27:22 | 5 | 24 |
| 5 |
|
Club Tijuana | 14 | 7 | 1 | 6 | 27:19 | 8 | 22 |
| 6 |
|
CF Monterrey | 14 | 6 | 3 | 5 | 27:19 | 8 | 21 |
| 7 |
|
Club León | 14 | 5 | 3 | 6 | 19:24 | -5 | 18 |
| 8 |
|
Mazatlán FC | 15 | 1 | 1 | 13 | 13:41 | -28 | 4 |
| 9 |
|
Atlético San Luis | 15 | 1 | 1 | 13 | 4:39 | -35 | 4 |
| Play-offs | |
| Play-offs |
