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| 12.02.2022 | 16:30 | Club Necaxa | - | CF Pachuca | 2:1 (1:1) | |
| 17:00 | Mazatlán FC | - | Club Tijuana | 1:3 (0:2) | ||
| 18:00 | UANL Tigres | - | CF Monterrey | 1:0 (1:0) | ||
| 18:30 | Gallos Blancos | - | Pumas UNAM | 1:3 (0:3) | ||
| 18:30 | Club León | - | Atlético San Luis | 1:0 (0:0) | ||
| 18:30 | Santos Laguna | - | Atlas Guadalajara | 4:3 (3:2) | ||
| 19:30 | FC Juárez | - | CF América | 1:0 (1:0) | ||
| 23:00 | Puebla FC | - | Deportivo Toluca | 0:4 (0:3) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 6 | 6 | 0 | 0 | 15:7 | 8 | 18 |
| 2 |
|
CF Pachuca | 5 | 3 | 0 | 2 | 13:7 | 6 | 9 |
| 3 |
|
Club Necaxa | 5 | 3 | 0 | 2 | 11:5 | 6 | 9 |
| 4 |
|
FC Juárez | 5 | 3 | 0 | 2 | 5:3 | 2 | 9 |
| 5 |
|
Deportivo Toluca | 6 | 2 | 2 | 2 | 8:7 | 1 | 8 |
| 6 |
|
Gallos Blancos | 6 | 2 | 2 | 2 | 4:8 | -4 | 8 |
| 7 |
|
CF América | 5 | 2 | 0 | 3 | 6:6 | 0 | 6 |
| 8 |
|
Cruz Azul | 5 | 0 | 1 | 4 | 4:12 | -8 | 1 |
| 9 |
|
Puebla FC | 5 | 0 | 1 | 4 | 0:11 | -11 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 5 | 5 | 0 | 0 | 10:3 | 7 | 15 |
| 2 |
|
Club Tijuana | 6 | 4 | 0 | 2 | 14:8 | 6 | 12 |
| 3 |
|
Deportivo Guadalajara | 5 | 3 | 2 | 0 | 9:2 | 7 | 11 |
| 4 |
|
Santos Laguna | 5 | 3 | 1 | 1 | 9:6 | 3 | 10 |
| 5 |
|
Atlas Guadalajara | 5 | 3 | 0 | 2 | 12:7 | 5 | 9 |
| 6 |
|
CF Monterrey | 6 | 2 | 1 | 3 | 7:8 | -1 | 7 |
| 7 |
|
Club León | 5 | 1 | 0 | 4 | 4:11 | -7 | 3 |
| 8 |
|
Atlético San Luis | 6 | 1 | 0 | 5 | 2:13 | -11 | 3 |
| 9 |
|
Mazatlán FC | 5 | 0 | 0 | 5 | 5:14 | -9 | 0 |
| Play-offs | |
| Play-offs |
