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| 18.02.2022 | 18:30 | Club León | - | Santos Laguna | 2:2 (2:1) | |
| 19.02.2022 | 16:00 | CF Pachuca | - | Gallos Blancos | 3:0 (2:0) | |
| 18:15 | Deportivo Guadalajara | - | Mazatlán FC | 2:0 (1:0) | ||
| 18:30 | Atlas Guadalajara | - | UANL Tigres | 5:2 (3:1) | ||
| 19:30 | FC Juárez | - | Cruz Azul | 3:1 (1:0) | ||
| 19:45 | CF América | - | Club Necaxa | 3:3 (1:2) | ||
| 21:45 | Club Tijuana | - | CF Monterrey | 1:1 (0:0) | ||
| 23:00 | Puebla FC | - | Pumas UNAM | 0:4 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 7 | 7 | 0 | 0 | 19:7 | 12 | 21 |
| 2 |
|
CF Pachuca | 6 | 4 | 0 | 2 | 16:7 | 9 | 12 |
| 3 |
|
FC Juárez | 6 | 4 | 0 | 2 | 8:4 | 4 | 12 |
| 4 |
|
Club Necaxa | 6 | 3 | 1 | 2 | 14:8 | 6 | 10 |
| 5 |
|
Deportivo Toluca | 6 | 2 | 2 | 2 | 8:7 | 1 | 8 |
| 6 |
|
Gallos Blancos | 7 | 2 | 2 | 3 | 4:11 | -7 | 8 |
| 7 |
|
CF América | 6 | 2 | 1 | 3 | 9:9 | 0 | 7 |
| 8 |
|
Cruz Azul | 6 | 0 | 1 | 5 | 5:15 | -10 | 1 |
| 9 |
|
Puebla FC | 6 | 0 | 1 | 5 | 0:15 | -15 | 1 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 6 | 5 | 0 | 1 | 12:8 | 4 | 15 |
| 2 |
|
Deportivo Guadalajara | 6 | 4 | 2 | 0 | 11:2 | 9 | 14 |
| 3 |
|
Club Tijuana | 7 | 4 | 1 | 2 | 15:9 | 6 | 13 |
| 4 |
|
Atlas Guadalajara | 6 | 4 | 0 | 2 | 17:9 | 8 | 12 |
| 5 |
|
Santos Laguna | 6 | 3 | 2 | 1 | 11:8 | 3 | 11 |
| 6 |
|
CF Monterrey | 7 | 2 | 2 | 3 | 8:9 | -1 | 8 |
| 7 |
|
Club León | 6 | 1 | 1 | 4 | 6:13 | -7 | 4 |
| 8 |
|
Atlético San Luis | 6 | 1 | 0 | 5 | 2:13 | -11 | 3 |
| 9 |
|
Mazatlán FC | 6 | 0 | 0 | 6 | 5:16 | -11 | 0 |
| Play-offs | |
| Play-offs |
