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| 08.10.2022 | 17:30 | Deportivo Toluca | - | Puebla FC | 3:1 (0:1) | |
| 18:00 | UANL Tigres | - | Club Tijuana | 1:0 (1:0) | ||
| 18:30 | Gallos Blancos | - | Cruz Azul | 0:0 (0:0) | ||
| 18:30 | Santos Laguna | - | Atlético San Luis | 4:0 (2:0) | ||
| 18:30 | Pumas UNAM | - | FC Juárez | 6:0 (2:0) | ||
| 18:30 | Atlas Guadalajara | - | CF Monterrey | 2:4 (1:2) | ||
| 18:30 | Club León | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| 09.10.2022 | 16:00 | Club Necaxa | - | CF América | 5:2 (2:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 14 | 11 | 2 | 1 | 37:15 | 22 | 35 |
| 2 |
|
Club Necaxa | 14 | 7 | 3 | 4 | 26:11 | 15 | 24 |
| 3 |
|
Deportivo Toluca | 14 | 7 | 3 | 4 | 29:20 | 9 | 24 |
| 4 |
|
CF Pachuca | 14 | 5 | 7 | 2 | 22:14 | 8 | 22 |
| 5 |
|
CF América | 14 | 6 | 3 | 5 | 27:25 | 2 | 21 |
| 6 |
|
Cruz Azul | 14 | 4 | 5 | 5 | 24:25 | -1 | 17 |
| 7 |
|
Gallos Blancos | 15 | 3 | 5 | 7 | 18:21 | -3 | 14 |
| 8 |
|
FC Juárez | 15 | 3 | 1 | 11 | 17:56 | -39 | 10 |
| 9 |
|
Puebla FC | 14 | 2 | 3 | 9 | 17:30 | -13 | 9 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Tijuana | 14 | 9 | 2 | 3 | 39:15 | 24 | 29 |
| 2 |
|
CF Monterrey | 14 | 7 | 6 | 1 | 37:21 | 16 | 27 |
| 3 |
|
Deportivo Guadalajara | 14 | 8 | 2 | 4 | 28:17 | 11 | 26 |
| 4 |
|
Santos Laguna | 14 | 7 | 3 | 4 | 34:21 | 13 | 24 |
| 5 |
|
UANL Tigres | 14 | 7 | 3 | 4 | 25:24 | 1 | 24 |
| 6 |
|
Atlas Guadalajara | 14 | 6 | 3 | 5 | 30:22 | 8 | 21 |
| 7 |
|
Club León | 15 | 6 | 3 | 6 | 26:21 | 5 | 21 |
| 8 |
|
Atlético San Luis | 15 | 2 | 0 | 13 | 15:60 | -45 | 6 |
| 9 |
|
Mazatlán FC | 14 | 1 | 0 | 13 | 14:47 | -33 | 3 |
| Play-offs | |
| Play-offs |
