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| U | Atlante | - | Atlético Morelia | 0:1 (0:1) | ||
| R | Atlético Morelia | - | Atlante | 1:1 (1:1) | ||
| U: 04.05.2021 23:00 | R: 08.05.2021 04:00 | Winnaars: Atlético Morelia | ||||
| U | Tepatitlán | - | Mineros de Zacatecas | 3:0 (0:0) | ||
| R | Mineros de Zacatecas | - | Tepatitlán | 1:1 (1:0) | ||
| U: 06.05.2021 00:00 | R: 09.05.2021 00:00 | Winnaars: Tepatitlán | ||||
