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| U | Mineros de Zacatecas | - | Atlético Morelia | 3:3 (1:2) | ||
| R | Atlético Morelia | - | Mineros de Zacatecas | 2:2 (1:1) | ||
| U: 27.04.2022 02:00 | R: 30.04.2022 00:00 | Winnaars: Atlético Morelia | ||||
| U | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 1:0 Toeg. | ||
| R | Alebrijes de Oaxaca | - | Cimarrones de Sonora | 0:0 (0:0) | ||
| U: 27.04.2022 04:05 | R: 01.05.2022 00:00 | Winnaars: Cimarrones de Sonora | ||||
| U | Atlante | - | Leones Negros | 2:0 (0:0) | ||
| R | Leones Negros | - | Atlante | 1:2 (1:1) | ||
| U: 29.04.2022 02:00 | R: 01.05.2022 23:00 | Winnaars: Atlante | ||||
| U | Cancún FC | - | Club Celaya | 0:1 (0:0) | ||
| R | Club Celaya | - | Cancún FC | 2:1 (2:1) | ||
| U: 29.04.2022 04:05 | R: 02.05.2022 01:05 | Winnaars: Club Celaya | ||||
