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| 22.02.2019 | 22:00 | Cruz Azul Hidalgo | - | Pumas UNAM II | 0:2 (0:1) | |
| 23.02.2019 | 03:30 | Atlético Reynosa | - | Deportivo Guadalajara II | 3:0 (2:0) | |
| 04:20 | Murciélagos FC | - | Coras de Nayarit | 0:1 (0:0) | ||
| 18:00 | Cimarrones de Sonora II | - | Dorados UACH | 0:1 (0:1) | ||
| 18:00 | Coyotes de Tlaxcala | - | Pioneros de Cancún | 1:2 (1:1) | ||
| 19:00 | Monarcas Morelia II | - | Correcaminos UAT II | 5:1 (2:0) | ||
| 22:00 | Real Zamora | - | Inter Playa | 2:0 (1:0) | ||
| 22:30 | Tuzos de la UAZ | - | Tuxtla FC | 1:0 (1:0) | ||
| 23:00 | Gavilanes de Matamoros | - | Tecos Fútbol Club | 3:0 (3:0) | ||
| 23:00 | Sporting Canamy | - | Club Irapuato | 1:3 (0:1) | ||
| 23:00 | Tepatitlán | - | Alacranes de Durango | 2:0 (0:0) | ||
| 23:00 | Yalmakan FC | - | Albinegros Orizaba | 0:2 (0:0) | ||
| 24.02.2019 | 03:00 | Reboceros de La Piedad | - | Deportivo Toluca II | 0:1 (0:1) | |
| 18:00 | Club Necaxa II | - | Loros UCOL | 2:5 (1:1) | ||
| 19:00 | Leones Negros II | - | Pacific F. C. | 4:2 (0:0) | ||
| 26.02.2019 | 00:00 | Cocodrilos de Tabasco | - | CF América II | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Irapuato | 22 | 16 | 4 | 2 | 39:14 | 25 | 56 |
| 2 |
|
Loros UCOL | 22 | 12 | 4 | 6 | 56:25 | 31 | 46 |
| 3 |
|
Deportivo Guadalajara II | 22 | 11 | 8 | 3 | 34:23 | 11 | 45 |
| 4 |
|
Tepatitlán | 22 | 12 | 6 | 4 | 39:26 | 13 | 44 |
| 5 |
|
Murciélagos FC | 22 | 12 | 4 | 6 | 41:23 | 18 | 43 |
| 6 |
|
Club Necaxa II | 22 | 11 | 7 | 4 | 28:22 | 6 | 43 |
| 7 |
|
Tuxtla FC | 22 | 12 | 4 | 6 | 36:20 | 16 | 42 |
| 8 |
|
Atlético Reynosa | 22 | 10 | 6 | 6 | 28:15 | 13 | 40 |
| 9 |
|
Tuzos de la UAZ | 22 | 10 | 8 | 4 | 34:25 | 9 | 40 |
| 10 |
|
Pumas UNAM II | 22 | 10 | 5 | 7 | 31:24 | 7 | 38 |
| 11 |
|
Dorados UACH | 22 | 9 | 6 | 7 | 24:21 | 3 | 37 |
| 12 |
|
Coras de Nayarit | 22 | 9 | 7 | 6 | 29:25 | 4 | 36 |
| 13 |
|
Cruz Azul Hidalgo | 22 | 9 | 5 | 8 | 26:22 | 4 | 36 |
| 14 |
|
Real Zamora | 22 | 10 | 4 | 8 | 27:26 | 1 | 36 |
| 15 |
|
Gavilanes de Matamoros | 22 | 9 | 6 | 7 | 31:25 | 6 | 35 |
| 16 |
|
Deportivo Toluca II | 22 | 9 | 6 | 7 | 32:29 | 3 | 35 |
| 17 |
|
Inter Playa | 22 | 8 | 7 | 7 | 26:24 | 2 | 33 |
| 18 |
|
Monarcas Morelia II | 22 | 8 | 7 | 7 | 39:25 | 14 | 32 |
| 19 |
|
Correcaminos UAT II | 22 | 7 | 6 | 9 | 25:32 | -7 | 30 |
| 20 |
|
Coyotes de Tlaxcala | 22 | 5 | 12 | 5 | 27:25 | 2 | 29 |
| 21 |
|
Reboceros de La Piedad | 22 | 5 | 8 | 9 | 28:33 | -5 | 27 |
| 22 |
|
Albinegros Orizaba | 22 | 7 | 5 | 10 | 15:28 | -13 | 27 |
| 23 |
|
Cocodrilos de Tabasco | 22 | 4 | 10 | 8 | 20:25 | -5 | 25 |
| 24 |
|
Tecos Fútbol Club | 22 | 5 | 5 | 12 | 27:35 | -8 | 25 |
| 25 |
|
Yalmakan FC | 22 | 4 | 8 | 10 | 23:32 | -9 | 22 |
| 26 |
|
Leones Negros II | 22 | 5 | 6 | 11 | 25:35 | -10 | 22 |
| 27 |
|
Sporting Canamy | 22 | 5 | 6 | 11 | 24:42 | -18 | 22 |
| 28 |
|
Pioneros de Cancún | 22 | 3 | 10 | 9 | 20:29 | -9 | 21 |
| 29 |
|
CF América II | 22 | 3 | 10 | 9 | 23:33 | -10 | 21 |
| 30 |
|
Alacranes de Durango | 22 | 4 | 8 | 10 | 16:28 | -12 | 21 |
| 31 |
|
Pacific F. C. | 22 | 3 | 5 | 14 | 21:50 | -29 | 16 |
| 32 |
|
Cimarrones de Sonora II | 22 | 2 | 3 | 17 | 10:63 | -53 | 9 |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Play-offs | |
| Degradatie |
