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| U | Pumas UNAM | - | CF América | 1:4 (1:3) | ||
| R | CF América | - | Pumas UNAM | 2:1 (1:1) | ||
| U: 03.05.2018 02:30 | R: 06.05.2018 02:00 | Winnaars: CF América | ||||
| U | Club Tijuana | - | CF Monterrey | 1:1 (0:1) | ||
| R | CF Monterrey | - | Club Tijuana | 1:2 (0:2) | ||
| U: 03.05.2018 04:30 | R: 06.05.2018 04:00 | Winnaars: Club Tijuana | ||||
| U | UANL Tigres | - | Santos Laguna | 2:0 (1:0) | ||
| R | Santos Laguna | - | UANL Tigres | 2:0 (1:0) | ||
| U: 04.05.2018 02:30 | R: 07.05.2018 01:00 | |||||
| U | Monarcas Morelia | - | Deportivo Toluca | 2:2 (0:1) | ||
| R | Deportivo Toluca | - | Monarcas Morelia | 2:2 (1:0) | ||
| U: 04.05.2018 04:30 | R: 06.05.2018 19:00 | |||||
