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| U | Puebla FC | - | Club León | 2:1 (2:1) | ||
| R | Club León | - | Puebla FC | 2:0 (2:0) | ||
| U: 26.11.2020 02:00 | R: 29.11.2020 02:00 | Winnaars: Club León | ||||
| U | Deportivo Guadalajara | - | CF América | 1:0 (0:0) | ||
| R | CF América | - | Deportivo Guadalajara | 1:2 (0:1) | ||
| U: 26.11.2020 04:06 | R: 29.11.2020 04:06 | Winnaars: Deportivo Guadalajara | ||||
| U | UANL Tigres | - | Cruz Azul | 1:3 (0:1) | ||
| R | Cruz Azul | - | UANL Tigres | 0:1 (0:0) | ||
| U: 27.11.2020 02:00 | R: 30.11.2020 01:30 | Winnaars: Cruz Azul | ||||
| U | CF Pachuca | - | Pumas UNAM | 0:1 (0:1) | ||
| R | Pumas UNAM | - | CF Pachuca | 0:0 (0:0) | ||
| U: 27.11.2020 04:06 | R: 29.11.2020 19:00 | Winnaars: Pumas UNAM | ||||
