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| U | Puebla FC | - | CF América | 1:1 (0:0) | ||
| R | CF América | - | Puebla FC | 3:2 (1:1) | ||
| U: 11.05.2022 04:05 | R: 15.05.2022 01:00 | Winnaars: CF América | ||||
| U | Atlético San Luis | - | CF Pachuca | 2:2 (1:1) | ||
| R | CF Pachuca | - | Atlético San Luis | 3:2 (0:0) | ||
| U: 12.05.2022 02:00 | R: 15.05.2022 03:05 | Winnaars: CF Pachuca | ||||
| U | Cruz Azul | - | UANL Tigres | 0:1 (0:1) | ||
| R | UANL Tigres | - | Cruz Azul | 0:1 (0:1) | ||
| U: 13.05.2022 02:00 | R: 16.05.2022 03:05 | |||||
| U | Deportivo Guadalajara | - | Atlas Guadalajara | 1:2 (0:2) | ||
| R | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| U: 13.05.2022 04:05 | R: 16.05.2022 01:00 | Winnaars: Atlas Guadalajara | ||||
