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| U | Santos Laguna | - | CF Monterrey | 0:0 (0:0) | ||
| R | CF Monterrey | - | Santos Laguna | 2:0 (1:0) | ||
| U: 11.05.2023 03:00 | R: 14.05.2023 03:06 | Winnaars: CF Monterrey | ||||
| U | Atlético San Luis | - | CF América | 1:3 (1:3) | ||
| R | CF América | - | Atlético San Luis | 1:2 (0:2) | ||
| U: 11.05.2023 05:10 | R: 14.05.2023 05:16 | Winnaars: CF América | ||||
| U | Atlas Guadalajara | - | Deportivo Guadalajara | 1:0 (1:0) | ||
| R | Deportivo Guadalajara | - | Atlas Guadalajara | 1:0 (0:0) | ||
| U: 12.05.2023 03:00 | R: 15.05.2023 03:05 | |||||
| U | UANL Tigres | - | Deportivo Toluca | 4:1 (3:1) | ||
| R | Deportivo Toluca | - | UANL Tigres | 3:1 (2:0) | ||
| U: 12.05.2023 05:10 | R: 14.05.2023 20:00 | Winnaars: UANL Tigres | ||||
